2,2-Difluoroacetyl chloride

Base Information

• Chemical Name: 2,2-Difluoroacetyl chloride
• CAS No.: 381-72-6
• Molecular Formula: C2H Cl F2 O
• Molecular Weight: 114.479
• Hs Code.: 2915900090
• European Community (EC) Number: 688-397-2
• DSSTox Substance ID: DTXSID00371681
• Nikkaji Number: J540.203D
• Wikidata: Q82159103
• Mol file: 381-72-6.mol

Synonyms:2,2-difluoroacetyl chloride;381-72-6;Difluoroacetyl chloride;2,2-DIFLUOROACETYLCHLORIDE;difluoroacetic acid chloride;MFCD00190230;difluoroacetylchloride;Acetyl chloride, difluoro-;SCHEMBL22044;Acetyl chloride, 2,2-difluoro-;DTXSID00371681;AKOS006229223;FT-0676369;EN300-7167560

Chemical Property of 2,2-Difluoroacetyl chloride

Chemical Property:

• Vapor Pressure: 790mmHg at 25°C
• Refractive Index: 1.327
• Boiling Point: 24°Cat760mmHg
• Flash Point: °C
• PSA: 17.07000
• Density: 1.407g/cm³
• LogP: 1.01690
• Storage Temp.: Keep Cold
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 113.9683987
• Heavy Atom Count: 6
• Complexity: 62.6

Purity/Quality:

99% ^*data from raw suppliers

DifluoroacetylChloride ^*data from reagent suppliers

Safty Information:

• Hazard Codes: C
• Statements: 20/21/22-35
• Safety Statements: 23-26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)Cl)(F)F

Technology Process of 2,2-Difluoroacetyl chloride

There total 10 articles about 2,2-Difluoroacetyl chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Ethyl 1,1,2,2-tetrafluoroethyl ether (512-51-6) → difluoroacetyl chloride (381-72-6) + ethene (74-85-1)

Guidance literature:

With calcium chloride; Temperature; Inert atmosphere; Autoclave; Heating;

Reference yield:

Ethyl 1,1,2,2-tetrafluoroethyl ether (512-51-6) → difluoroacetyl chloride (381-72-6) + ethene (74-85-1) + chloroethane (75-00-3)

Guidance literature:

With calcium chloride; Temperature; Inert atmosphere; Heating;

Reference yield:

1,1,2,2-tetrafluoro-1-methoxyethane (425-88-7) → methylene chloride (74-87-3) + difluoroacetyl chloride (381-72-6)

Guidance literature:

With calcium chloride; at 200 ℃; Temperature; Inert atmosphere; Autoclave;

upstream raw materials:

(1,1,2,2-Tetrafluoro-ethoxymethyl)-benzene

2-fluorosulfonyl-2,2-difluoroacetyl chloride

fluorosulphonic acid

chlorosulfonic acid

Downstream raw materials:

1,1,1,3,3-pentafluoro-2-propanone

difluoroethanol

difluoro-acetic acid-(N-methyl-anilide)

4,4-Difluoro-2,2-dimethyl-3-oxo-butyryl chloride

Refernces

• 1、 -. "Method for Producing Difluoroacetyl Chloride". Paragraph 0093. . Retrieved 2013/03/26.