2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE

Base Information

• Chemical Name: 2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE
• CAS No.: 72943-43-2
• Molecular Formula: C10H8IN3O
• Molecular Weight: 313.098
• Mol file: 72943-43-2.mol

Synonyms:4(1H)-Pyrimidinone,2-amino-5-iodo-6-phenyl- (9CI);2-Amino-5-iodo-6-phenyl-4(1H)-pyrimidinone;2-Amino-5-iodo-6-phenyl-4(3H)-pyrimidinone;2-Amino-5-iodo-6-phenyl-4-pyrimidinol;2-Amino-5-iodo-6-phenyl-4-pyrimidinone;5-Iodo-6-phenylisocytosine;PNU 54462;U 54462;

Chemical Property of 2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE

Chemical Property:

• Vapor Pressure: 8.45E-07mmHg at 25°C
• Refractive Index: 1.762
• Boiling Point: 405.9 °C at 760 mmHg
• Flash Point: 199.3 °C
• PSA: 71.77000
• Density: 1.98 g/cm³
• LogP: 2.20490

Purity/Quality:

99% ^*data from raw suppliers

2-Amino-5-iodo-6-phenylpyrimidin-4(1H)-one 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE

There total 4 articles about 2-AMINO-5-IODO-6-PHENYL-4(1H)-PYRIMIDINONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-amino-6-phenyl-3H-pyrimidin-4-one (56741-94-7) → 2-amino-5-iodo-6-phenylpyrimidin-4(3H)-one (72943-43-2)

Guidance literature:

With sodium hydroxide; iodine; In chloroform;

DOI:10.1021/jm00177a004

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-amino-5-iodo-6-phenylpyrimidin-4(3H)-one (72943-43-2)

Guidance literature:

Multi-step reaction with 2 steps

1: ethanol; toluene / Heating

2: sodium hydroxide, iodine / H₂O; CHCl₃ / 4 h

With sodium hydroxide; iodine; In ethanol; chloroform; water; toluene;

DOI:10.1021/jm00150a018

Reference yield:

ethyl 3-oxo-3-phenylpropionate (94-02-0) → 2-amino-5-iodo-6-phenylpyrimidin-4(3H)-one (72943-43-2)

Guidance literature:

Multi-step reaction with 2 steps

2: I₂, 1 N NaOH / CHCl₃

With sodium hydroxide; iodine; In chloroform;

DOI:10.1021/jm00177a004

upstream raw materials:

2-amino-6-phenyl-3H-pyrimidin-4-one

ethyl 3-oxo-3-phenylpropionate

benzoyl chloride

Downstream raw materials:

2-(acetylamino)-5-iodo-6-phenyl-4(3H)-pyrimidinone

Refernces

• 1、 Wierenga,Skulnick,Stringfellow,Weed,Renis,Eidson. "5-Substituted 2-amino-6-phenyl-4(3H)-pyrimidinones. Antiviral- and interferon-inducing agents". . p. 237 - 239. Retrieved 2007/10/02.