2-Oxo-N,2-diphenylacetamide

Base Information

• Chemical Name: 2-Oxo-N,2-diphenylacetamide
• CAS No.: 4732-66-5
• Molecular Formula: C14H11 N O2
• Molecular Weight: 225.247
• NSC Number: 84912
• DSSTox Substance ID: DTXSID40292700
• Nikkaji Number: J1.038.315C
• Wikidata: Q82031111
• Mol file: 4732-66-5.mol

Synonyms:2-Oxo-N,2-diphenylacetamide;4732-66-5;benzoylformanilide;NSC84912;Glyoxylamide, N,2-diphenyl-;SCHEMBL6511264;2-Oxo-N,2-diphenylacetamide #;DTXSID40292700;RFHPCPUJOXAXKQ-UHFFFAOYSA-N;NSC-84912

Chemical Property of 2-Oxo-N,2-diphenylacetamide

Chemical Property:

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 46.17000
• Density: 1.238g/cm³
• LogP: 2.58100
• XLogP3: 2.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 225.078978594
• Heavy Atom Count: 17
• Complexity: 276

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(=O)C(=O)NC2=CC=CC=C2

Technology Process of 2-Oxo-N,2-diphenylacetamide

There total 64 articles about 2-Oxo-N,2-diphenylacetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

phenylacetylene (536-74-3) + aniline (62-53-3) → 2-oxo-N,2-diphenylacetamide (4732-66-5)

Guidance literature:

With oxygen; copper(l) chloride; In methanol; acetonitrile; at 20 ℃; for 10h; Reagent/catalyst; Concentration; Irradiation;

DOI:10.1039/c4gc01623h

Reference yield: 92.0%

2,2,4,4,4-pentafluoro-3,3-dihydroxy-1-phenylbutan-1-one (1259998-89-4) + Nitrosobenzene (586-96-9) → 2-oxo-N,2-diphenylacetamide (4732-66-5)

Guidance literature:

With triethylamine; lithium bromide; In acetonitrile; at 20 ℃; for 0.0833333h; Reagent/catalyst; Solvent; Inert atmosphere;

DOI:10.1021/acs.orglett.8b01900

Reference yield: 92.0%

Benzoylformic acid (611-73-4) + benzoyl azide (582-61-6) → 2-oxo-N,2-diphenylacetamide (4732-66-5)

Guidance literature:

at 60 ℃; for 6h;

upstream raw materials:

α-oximino-2-phenylacetanilide

3-oxo-2-phenyl-propionic acid anilide

furan

phenyl-glyoxal-2-(N-phenyl oxime )

Downstream raw materials:

4-(4-bromo-phenyl)-2-hydroxy-4-oxo-2-phenyl-butyric acid anilide

3,3-dicyano-2-phenyl-acrylic acid anilide

1,3,4-triphenyl-2,5-dihydro-1H-2,5-azoledione

2-hydroxy-3-nitro-2-phenyl-propionic acid anilide

Refernces

• 1、 Chen, Xi,Wang, Muhua,Zhang, Xinying,Fan, Xuesen. "A novel synthesis of diversely functionalized 1,2,4-triones through the homo- and cross-coupling reactions of β-keto sulfoxonium ylides". . . Retrieved 2020.
• 2、 Polushina,Zavarzin,Krayushkin,Rodionova,Yarovenko. "Desulfurizing agent for thioamides". . p. 383 - 385. Retrieved 2021/03/03.
• 3、 Bhanage, Bhalchandra M.,Chaurasia, Shivkumar R.,Mishra, Ashish A.. "Ru-g-C3N4as a highly active heterogeneous catalyst for transfer hydrogenation of α-keto amide into β-aminol or α-hydroxyl amide". supporting information. p. 10578 - 10585. Retrieved 2020/07/14.