ETHYL 2-(2-FORMYLPHENOXY)ACETATE

Base Information

• Chemical Name: ETHYL 2-(2-FORMYLPHENOXY)ACETATE
• CAS No.: 41873-61-4
• Molecular Formula: C11H12 O4
• Molecular Weight: 208.214
• Hs Code.: 2918990090
• Mol file: 41873-61-4.mol

Synonyms:Aceticacid, (2-formylphenoxy)-, ethyl ester (9CI);2-(Ethoxycarbonylmethoxy)benzaldehyde; Ethyl (2-formylphenoxy)acetate; NSC403938

Chemical Property of ETHYL 2-(2-FORMYLPHENOXY)ACETATE

Chemical Property:

• Vapor Pressure: 0.000288mmHg at 25°C
• Melting Point: 45-47°C
• Boiling Point: 322°Cat760mmHg
• Flash Point: 141.5°C
• PSA: 52.60000
• Density: 1.169g/cm³
• LogP: 1.44100
• Sensitive.: Air Sensitive

Purity/Quality:

99% ^*data from raw suppliers

Ethyl2-(2-Formylphenoxy)acetate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-(2-FORMYLPHENOXY)ACETATE

There total 12 articles about ETHYL 2-(2-FORMYLPHENOXY)ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

salicylaldehyde (90-02-8) + ethyl bromoacetate (105-36-2) → ethyl (2-formylphenoxy)acetate (41873-61-4)

Guidance literature:

With potassium carbonate; In acetone; for 20h; Heating;

DOI:10.1002/ardp.19953280307

Reference yield: 93.0%

salicylaldehyde (90-02-8) → ethyl (2-formylphenoxy)acetate (41873-61-4)

Guidance literature:

With potassium carbonate; potassium iodide; In acetonitrile; at 20 ℃;

DOI:10.1021/jacs.1c10162

Reference yield: 92.0%

ethanol (64-17-5) + 2-Formylphenoxyacetic acid (6280-80-4) → ethyl (2-formylphenoxy)acetate (41873-61-4)

Guidance literature:

With aluminum potassium sulfate dodecahydrate; In neat (no solvent); at 80 ℃; for 12h; Time; Temperature; Green chemistry;

upstream raw materials:

salicylaldehyde

ethyl bromoacetate

ethanol

2-Formylphenoxyacetic acid

Downstream raw materials:

5,10,15,20-tetrakis<2-(ethoxycarbonylmethoxy)phenyl>porphyrin

[2-(1-Hydroxy-4-methyl-5-pyridin-3-yl-1H-imidazol-2-yl)-phenoxy]-acetic acid ethyl ester

[2-((E)-2-Diisopropylcarbamoyl-vinyl)-phenoxy]-acetic acid ethyl ester

(2-thiosemicarbazonomethyl-phenoxy)-acetic acid

Refernces

• 1、 Cai, Zhongzheng,Fan, Hua-Zhong,Gong, Fu-Long,Tu, Yi-Min,Wang, Xue-Mei,Yang, Xing,Zhu, Jian-Bo. "Biobased High-Performance Aromatic-Aliphatic Polyesters with Complete Recyclability". supporting information. p. 20591 - 20597. Retrieved 2021/12/09.
• 2、 Hussein, Waleed M.,Feder, Daniel,Schenk, Gerhard,Guddat, Luke W.,McGeary, Ross P.. "Purple acid phosphatase inhibitors as leads for osteoporosis chemotherapeutics". . p. 462 - 479. Retrieved 2018/08/21.