DIMETHYLPHOSPHINIC CHLORIDE

Base Information

• Chemical Name: DIMETHYLPHOSPHINIC CHLORIDE
• CAS No.: 1111-92-8
• Molecular Formula: C2H6 Cl O P
• Molecular Weight: 112.496
• Hs Code.: 2903199000
• European Community (EC) Number: 214-187-3
• DSSTox Substance ID: DTXSID40149503
• Nikkaji Number: J217.229A
• Wikidata: Q72471449
• Mol file: 1111-92-8.mol

Synonyms:Chlorodimethylphosphineoxide; Dimethylphosphinic chloride; Dimethylphosphinoyl chloride;Dimethylphosphinyl chloride

Chemical Property of DIMETHYLPHOSPHINIC CHLORIDE

Chemical Property:

• Appearance/Colour: yellow to pink to tan crystals or crystalline. powder and chunks
• Vapor Pressure: 0.385mmHg at 25°C
• Melting Point: 65-71 °C(lit.)
• Refractive Index: 1.39
• Boiling Point: 204 °C at 760 mmHg
• Flash Point: 77.2 °C
• PSA: 26.88000
• Density: 1.158 g/cm³
• LogP: 1.76290
• Storage Temp.: Refrigerator, under inert atmosphere
• Sensitive.: Moisture Sensitive
• Solubility.: Chloroform (Sparingly), Methanol (Slightly)
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 111.9844795
• Heavy Atom Count: 5
• Complexity: 64

Purity/Quality:

99% ^*data from raw suppliers

Dimethylphosphinic chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): C
• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-27-28-36/37/39-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CP(=O)(C)Cl
• Uses: Dimethylphosphinic chloride is used in the protection of amino acids in peptide synthesis. It initiates the luminescence of ABI-NH2. It is utilized in the reactivity of organophosphate-based nerve gases such as sarin gas. Dimethylphosphinic chloride was used in preparation of dimethyl-ethynylphosphine oxide.

Technology Process of DIMETHYLPHOSPHINIC CHLORIDE

There total 6 articles about DIMETHYLPHOSPHINIC CHLORIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

tetramethyl-diphosphine disulphide (3676-97-9) → dimethylphosphinic acid chloride (1111-92-8)

Guidance literature:

With thionyl chloride;

Reference yield:

dimethylphosphinic acid N,N-dimethylamide (50663-05-3) → N,N-dimethylammonium chloride (506-59-2) + dimethylphosphinic acid chloride (1111-92-8)

Guidance literature:

With hydrogenchloride; In chloroform; Mechanism;

Reference yield:

dimethylphosphinic acid (3283-12-3) → dimethylphosphinic acid chloride (1111-92-8)

Guidance literature:

With thionyl chloride;

upstream raw materials:

dimethylphosphinic acid

tetramethyl-diphosphine disulphide

dimethylphosphinic acid N,N-dimethylamide

dimethyl-phosphinic acid ; potassium-salt

Downstream raw materials:

4-chlorophenyl dimethylphosphinate

4-acetylphenyl dimethylphosphinate

4-Ethoxycarbonylphenyl-dimethylphosphinat

p-nitrophenyl dimethyl phosphinate

Refernces

• 1、 Norlin, Rikard,Juhlin, Lars,Lind, Per,Trogen, Lars. "α-haloenamines as reagents for the conversion of phosphorus oxyacids to their halogenated analogues". . p. 1765 - 1770. Retrieved 2007/10/03.
• 2、 Ramage, Robert,Atrash, Butrus,Hopton, David,Parrot, Maxwell J.. "Evaluation of Phosphinic Acid Derivatives as Reagents For Amine Protection in Peptide Synthesis". . p. 1217 - 1226. Retrieved 2007/10/02.