2,3,5-Trichloropyridine

Base Information

• Chemical Name: 2,3,5-Trichloropyridine
• CAS No.: 16063-70-0
• Molecular Formula: C5H2Cl3N
• Molecular Weight: 182.437
• Hs Code.: 29333990
• European Community (EC) Number: 407-270-2,627-924-2
• DSSTox Substance ID: DTXSID40166952
• Nikkaji Number: J38.527A
• Wikidata: Q72510386
• Mol file: 16063-70-0.mol

Synonyms:2,3,5-TRICHLOROPYRIDINE;16063-70-0;2,3,5-TRICHLORO PYRIDINE;Pyridine, 2,3,5-trichloro-;516063-70-0;2,3,5-Trichloro-pyridine;BRN 0119384;MFCD00043007;EC 407-270-2;2,3,6-Trichloro-pyridine;2, 3, 5-trichloropyridine;SCHEMBL550269;DTXSID40166952;2,3,5-Trichloropyridine, 99%;HMS1608M01;BCP21114;STK762573;AKOS000120311;AC-8281;AM62369;CS-W001198;FG-0503;PB48080;LS-132112;EU-0067746;FT-0602838;FT-0694429;T1479;EN300-16777;P20057;A810156;AF-834/25001439;SR-01000396486;J-506895;Q-101461;SR-01000396486-1

Chemical Property of 2,3,5-Trichloropyridine

Chemical Property:

• Appearance/Colour: Beige powder
• Vapor Pressure: 0.213mmHg at 25°C
• Melting Point: 46-50 °C(lit.)
• Refractive Index: 1.572
• Boiling Point: 215.7 °C at 760 mmHg
• PKA: -2.92±0.10(Predicted)
• Flash Point: 104.7 °C
• PSA: 12.89000
• Density: 1.539 g/cm³
• LogP: 3.04180
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• Water Solubility.: Slightly soluble in water.
• XLogP3: 3.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 0
• Exact Mass: 180.925282
• Heavy Atom Count: 9
• Complexity: 98.2

Purity/Quality:

99% ^*data from raw suppliers

2,3,5-Trichloropyridine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 52/53-36/37/38
• Safety Statements: 61-37/39-26

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1=C(C=NC(=C1Cl)Cl)Cl
• Uses: 2,3,5-Trichloropyridine may be used in the synthesis of 3,5-dichloro-2-arylpyridines via palladium acetate-catalyzed ligand-free Suzuki reaction with arylboronic acids.

Technology Process of 2,3,5-Trichloropyridine

There total 36 articles about 2,3,5-Trichloropyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.1%

2,3,5,6-tetrachloropyridine (2402-79-1) → 2,3,5-trichloropyridine (16063-70-0)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; potassium hydroxide; In 5,5-dimethyl-1,3-cyclohexadiene; water; at 60 ℃; for 6h; under 4500.45 Torr; Reagent/catalyst; Solvent; Pressure; Autoclave;

Reference yield: 96.4%

2,3,4,5-tetrachloro-pyridine (2808-86-8) → 2,3,5-trichloropyridine (16063-70-0)

Guidance literature:

With tetramethylammonium methylphosphonic acid methyl ester; dimethyl methane phosphonate; zinc; In water; at 85 ℃; other ammonium salts; other methylphosphonates;other solvent(s). Object of study: selectivity of reaction;

Reference yield: 95.0%

3,5,6-trichloro-2-hydrazinopyridine (55933-94-3) → 2,3,5-trichloropyridine (16063-70-0)

Guidance literature:

upstream raw materials:

pyridine

phosgene

3,5-dichloro-1-methyl-1H-pyridin-2-one

2,3,4,5-tetrachloro-pyridine

Downstream raw materials:

3,5-dichloro-2-methoxypyridine

3,5-dichloropyridin-2-amine

(3,5-dichloro-2-pyridyl)hydrazine

5-chloro-1,2-dimethoxypyridine

Refernces

• 1、 Zhong, Ping,Hu, Huanan,Guo, Shengrong. "Direct formation of 2,3,5-trichloropyridine and its nucleophilic displacement reactions in ionic liquid". . p. 4301 - 4311. Retrieved 2004.
• 2、 -. "Synthesis method of 2, 3, 5-trichloropyridine". Paragraph 0011; 0032-0047. . Retrieved 2021/01/25.
• 3、 -. "Preparation method of 2, 3, 5-trichloropyridine". Paragraph 0019-0042. . Retrieved 2020/11/23.