phenylalanine amide

Base Information

• Chemical Name: phenylalanine amide
• CAS No.: 60058-39-1
• Molecular Formula: C₉H₁₂N₂O
• Molecular Weight: 164.207
• Mol file: 60058-39-1.mol

Synonyms:Benzenepropanamide,a-amino-, (?à)-; Hydrocinnamamide, a-amino-, DL- (8CI); (?à)-a-Aminobenzenepropanamide; DL-Phenylalaninamide; DL-Phenylalanineamide; DL-a-Aminohydrocinnamamide

Chemical Property of phenylalanine amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenylalanine amide

There total 24 articles about phenylalanine amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

(2R,3S)-(-)-3-phenylaziridine-2-carboxamide → 3-phenylpropionamide (102-93-2) + D-Phenylalaninamide (5241-58-7,5241-59-8,17193-31-6,60058-39-1)

Guidance literature:

With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 2.5h;

DOI:10.1021/jo101377j

Reference yield: 86.0%

D-phenylalanine methyl ester hydrochloride (13033-84-6) → D-Phenylalaninamide (5241-58-7,5241-59-8,17193-31-6,60058-39-1)

Guidance literature:

With ammonium hydroxide; at 20 ℃; for 12h;

Reference yield: 77.0%

D-phenylalanine methyl ester (21685-51-8) → D-Phenylalaninamide (5241-58-7,5241-59-8,17193-31-6,60058-39-1)

Guidance literature:

With ammonia; Ambient temperature;

upstream raw materials:

phenylalanine amide hydrochloride

D-phenylalanine methyl ester

D-phenylalanine methyl ester hydrochloride

(-)-1-<(1-cyano-2-phenylethyl)amino>-2R-methyl-5R-(1-methylethenyl)cyclohexane-1R,3R-dicarbonitrile

Downstream raw materials:

methyl ester of malonyl-D-phenylalanine amide

Z-β-homo-Asp(OBut)-D-Phe-NH2

Boc-Tyr-D-Ala-Phe-Gly-D-Phe-NH₂

(R)-3-phenylpropane-1,2-diamine

Refernces

• 1、 Cianni, Lorenzo,Lemke, Carina,Gilberg, Erik,Feldmann, Christian,Rosini, Fabiana,Rocho, Fernanda Dos Reis,Ribeiro, Jean F. R.,Tezuka, Daiane Y.,Lopes, Carla D.,de Albuquerque, Sérgio,Bajorath, Jürgen,Laufer, Stefan,Leit?o, Andrei,Gütschow, Michael,Montanariid, Carlos A.. "Mapping the s1 and s1’ subsites of cysteine proteases with new dipeptidyl nitrile inhibitors as trypanocidal agents". . . Retrieved 2020/04/24.
• 2、 Nojiri, Masutoshi,Taoka, Naoaki,Yasohara, Yoshihiko. "Characterization of an enantioselective amidase from Cupriavidus sp. KNK-J915 (FERM BP-10739) useful for enzymatic resolution of racemic 3-piperidinecarboxamide". . p. 136 - 142. Retrieved 2014/12/10.