4-Methyl-2-phenylquinoline

Base Information

• Chemical Name: 4-Methyl-2-phenylquinoline
• CAS No.: 4789-76-8
• Molecular Formula: C16H13 N
• Molecular Weight: 219.286
• Hs Code.: 2933499090
• NSC Number: 42810
• DSSTox Substance ID: DTXSID10197314
• Nikkaji Number: J122.313E
• Wikidata: Q83070214
• ChEMBL ID: CHEMBL459713
• Mol file: 4789-76-8.mol

Synonyms:4-METHYL-2-PHENYLQUINOLINE;4789-76-8;Quinoline, 4-methyl-2-phenyl-;Lepidine, 2-phenyl-;2-Phenyllepidine;4-METHYL-2-PHENYL-QUINOLINE;2-phenyl-4-methylquinoline;4-Methyl-2-phenyl-chinolin;NSC42810;2-Phenylchinolin-4-carbon;SCHEMBL951744;CHEMBL459713;DTXSID10197314;NSC 42810;NSC-42810;AKOS003621304;SB70858

Chemical Property of 4-Methyl-2-phenylquinoline

Chemical Property:

• Vapor Pressure: 2.3E-05mmHg at 25°C
• Boiling Point: 370.8°Cat760mmHg
• Flash Point: 161.4°C
• PSA: 12.89000
• Density: 1.105g/cm³
• LogP: 4.21020
• Storage Temp.: 2-8°C
• XLogP3: 4.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 219.104799419
• Heavy Atom Count: 17
• Complexity: 244

Purity/Quality:

98.5% ^*data from raw suppliers

4-methyl-2-phenylquinoline 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CC1=CC(=NC2=CC=CC=C12)C3=CC=CC=C3

Technology Process of 4-Methyl-2-phenylquinoline

There total 124 articles about 4-Methyl-2-phenylquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

2-aminoacetophenone (551-93-9) + acetophenone (98-86-2) → 4-methyl-2-phenylquinoline (4789-76-8)

Guidance literature:

With Silica-supported H₃PW₁₂O₄₀ catalyst; at 100 ℃; for 0.166667h; Neat (no solvent);

Reference yield: 96.0%

2-bromo-4-methyl-quinoline (64658-04-4) + phenylboronic acid (98-80-6) → 4-methyl-2-phenylquinoline (4789-76-8)

Guidance literature:

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In ethanol; water; toluene; for 14h; Inert atmosphere; Reflux;

Reference yield: 93.0%

2-aminoacetophenone (551-93-9) + phenylacetylene (536-74-3) → 4-methyl-2-phenylquinoline (4789-76-8)

Guidance literature:

With ammonium hexafluorophosphate; silver trifluoromethanesulfonate; (1,3-bis(2,6-di(iPr)C₆H₃)-1,3-dihydroimidazol-2-ylidene)AuCl; In acetonitrile; at 150 ℃; for 0.5h; Irradiation;

DOI:10.1021/ol070814l

upstream raw materials:

C₆H₄NCH₂CHCCH₂

diethyl ether

phenyllithium

2-aminoacetophenone

Downstream raw materials:

4-(4-methyl-quinolin-2-yl)-phenol

4-(4-methyl-[2]quinolyl)-aniline

N,N-diethyl-N'-(2-phenyl-[4]quinolylmethyl)-propanediyldiamine

4-methyl-2-(4-nitrophenyl)quinoline

Refernces

• 1、 Kim, Hee Un,Jang, Jae-Ho,Park, Hea Jung,Jung, Byung Jun,Song, Wook,Lee, Jun Yeob,Hwang, Do-Hoon. "Highly efficient and spectrally stable white organic light-emitting diodes using new red heteroleptic Iridium(III) complexes". . p. 363 - 372. Retrieved 2018.
• 2、 Cui, Yan-Ying,Na, Jin-He,Guo, Meng-Meng,Huang, Jie-Ying,Chu, Xue-Qiang,Rao, Weidong,Shen, Zhi-Liang. "Cobalt-catalyzed cross-coupling of nitrogen-containing heterocyclic phosphonium salts with arylmagnesium reagents". supporting information. . Retrieved 2022/02/16.
• 3、 -. "Novel anti-solvent quenching near-infrared two-zone dye and preparation method thereof Preparation method and application thereof". Paragraph 0031-0037. . Retrieved 2021/11/26.