6-Cyano-7-nitroquinoxaline-2,3-dione

Base Information

• Chemical Name: 6-Cyano-7-nitroquinoxaline-2,3-dione
• CAS No.: 115066-14-3
• Molecular Formula: C9H4N4O4
• Molecular Weight: 232.1525
• Hs Code.: 29335990
• European Community (EC) Number: 878-456-2
• UNII: 6OTE87SCCW
• DSSTox Substance ID: DTXSID40893918
• Nikkaji Number: J126.315C
• Wikipedia: CNQX
• Wikidata: Q4386534,Q27458884
• Metabolomics Workbench ID: 70081
• ChEMBL ID: CHEMBL222418
• Mol file: 115066-14-3.mol

Synonyms:1,4-dihydro-2,3-dihydroxy-7-nitro-6-quinoxalinecarbonitrile;6 Cyano 2,3 dihydroxy 7 nitroquinoxaline;6 Cyano 7 nitroquinoxaline 2,3 dione;6-Cyano-2,3-dihydroxy-7-nitroquinoxaline;6-Cyano-7-nitroquinoxaline-2,3-dione;CNQX;FG 9065;FG-9065;FG9065

Chemical Property of 6-Cyano-7-nitroquinoxaline-2,3-dione

Chemical Property:

• Appearance/Colour: pale yellow solid
• Vapor Pressure: 0.001mmHg at 25°C
• Melting Point: 300 °C
• Refractive Index: 1.803
• Boiling Point: 659.3 °C at 760 mmHg
• PKA: 8.16±0.20(Predicted)
• Flash Point: 352.6 °C
• PSA: 135.33000
• Density: 1.71 g/cm³
• LogP: 0.51948
• Storage Temp.: Desiccate at RT
• Solubility.: H2O: 10 mg/mL
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 0
• Exact Mass: 232.02325462
• Heavy Atom Count: 17
• Complexity: 434

Purity/Quality:

98%,99%, ^*data from raw suppliers

CNQX disodium salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Safety Statements: 22-24/25

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=C(C(=CC2=C1NC(=O)C(=O)N2)[N+](=O)[O-])C#N
• Uses: CNQX is a competitive, non-NMDA glutamate receptor antagonist (IC50s = 0.3 and 1.5 μM for AMPA and kainate receptors, respectively, versus IC50 = 25 μM for NMDA receptors). This compound has been used to specifically target AMPA and kainate receptor responses and thus differentiate from that of NMDA receptors. CNQX disodium salt hydrate has been used as:as a competitive non-NMDA receptor antagonist and competitive AMPA/kainate receptor antagonist in neuronal cultures(110)as a glutamatergic blockers for measuring inhibitory postsynaptic currents in projection neurons(111)as a AMPA glutamate receptor antagonist prefrontal cortex neurons(112) A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively