2-Hydroxyethyl laurate

Base Information

• Chemical Name: 2-Hydroxyethyl laurate
• CAS No.: 4219-48-1
• Deprecated CAS: 8034-23-9
• Molecular Formula: C14H28O3
• Molecular Weight: 244.375
• Hs Code.: 2915900090
• European Community (EC) Number: 224-159-2,618-396-4
• NSC Number: 406158
• UNII: GL702C7T0M
• DSSTox Substance ID: DTXSID0063363
• Nikkaji Number: J47.552A
• Wikidata: Q27896017
• RXCUI: 1363614
• Mol file: 4219-48-1.mol

Synonyms:laurox 9;laurox-9

Chemical Property of 2-Hydroxyethyl laurate

Chemical Property:

• Vapor Pressure: 2.28E-06mmHg at 25°C
• Melting Point: 31-32 °C
• Boiling Point: 352.3°C at 760 mmHg
• PKA: 13.90±0.10(Predicted)
• Flash Point: 136.9°C
• PSA: 46.53000
• Density: 0.937g/cm³
• LogP: 3.44280
• XLogP3: 4.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 13
• Exact Mass: 244.20384475
• Heavy Atom Count: 17
• Complexity: 169

Purity/Quality:

98%Min ^*data from raw suppliers

EthyleneGlycolMonolaurate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Other Classes -> Polyoxyethylenes
• Canonical SMILES: CCCCCCCCCCCC(=O)OCCO
• Uses: Ethylene Glycol Monolaurate was used as a reactant in the synthesis of neuritogenic gentiside derivatives.

Technology Process of 2-Hydroxyethyl laurate

There total 17 articles about 2-Hydroxyethyl laurate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

2-undecanyl-1,3-dioxolane (5735-88-6) → ethylene glycol monolaurate (4219-48-1)

Guidance literature:

With anthraquinone-2-carboxylic acid; oxygen; In ethyl acetate; for 3h; Irradiation; Green chemistry;

DOI:10.1016/j.tetlet.2015.02.104

Reference yield: 62.0%

n-dodecanoyl chloride (112-16-3) + ethylene glycol (107-21-1) → ethylene glycol monolaurate (4219-48-1)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1248/cpb.c15-00795

Reference yield:

Iodoethanol (624-76-0) + lauric acid (143-07-7) → ethylene glycol monolaurate (4219-48-1)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 40 ℃;

upstream raw materials:

oxirane

lauric acid

triglycol borate

lauric acid-(2-iodo-ethyl ester)

Downstream raw materials:

lauric acid

ethane-1,2-diyl bis(hydrogen sulfate)

sulfuric acid mono-(2-lauroyloxy-ethyl ester)

C₂₆H₄₄ClO₅P

Refernces

• 1、 -. "LIPO-GLYCOPEPTIDE CLEAVABLE DERIVATIVES AND USES THEREOF". Paragraph 233; 234. . Retrieved 2020/06/10.
• 2、 Yamaguchi, Tomoaki,Kudo, Yasuhisa,Hirashima, Shin-ichi,Yamaguchi, Eiji,Tada, Norihiro,Miura, Tsuyoshi,Itoh, Akichika. "Facile and efficient synthesis of hydroxyalkyl esters from cyclic acetals through aerobic photo-oxidation using anthraquinone-2-carboxylic acid". . p. 1973 - 1975. Retrieved 2015/03/18.