(2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone

Base Information

• Chemical Name: (2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone
• CAS No.: 6131-38-0
• Molecular Formula: C15H14O4
• Molecular Weight: 258.274
• NSC Number: 56770
• UNII: MTZ4N6TC5L
• DSSTox Substance ID: DTXSID10210214
• Nikkaji Number: J1.096.676K
• Wikidata: Q83084817
• Mol file: 6131-38-0.mol

Synonyms:(2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone;6131-38-0;Methanone, (2-hydroxy-4-methoxyphenyl)(4-methoxyphenyl)-;NSC 56770;MTZ4N6TC5L;2-hydroxy-4,4'-dimethoxybenzophenone;BRN 1982245;NSC-56770;4,4'-Dimethoxy-2-hydroxybenzophenone;4-08-00-03164 (Beilstein Handbook Reference);NSC56770;UNII-MTZ4N6TC5L;NCIOpen2_002283;SCHEMBL228916;DTXSID10210214;AKOS024353458;LS-91273;BENZOPHENONE, 2-HYDROXY-4,4'-DIMETHOXY-;(2-Hydroxy-4-methoxyphenyl) (4-methoxyphenyl) methanone;(2-Hydroxy-4-methoxyphenyl) (4-methoxyphenyl)methanone

Chemical Property of (2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone

Chemical Property:

• Vapor Pressure: 1.71E-07mmHg at 25°C
• Boiling Point: 415.4°C at 760 mmHg
• Flash Point: 155.5°C
• Density: 1.206g/cm³
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 4
• Exact Mass: 258.08920892
• Heavy Atom Count: 19
• Complexity: 297

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(=O)C2=C(C=C(C=C2)OC)O

Technology Process of (2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone

There total 16 articles about (2-Hydroxy-4-methoxyphenyl)(4-methoxyphenyl)methanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

2,4,4'-trimethoxybenzophenone (4038-15-7) → 2-hydroxy-4,4'-dimethoxybenzophenone (6131-38-0)

Guidance literature:

With beryllium(II) chloride; In toluene; for 3h; Heating;

DOI:10.1016/0040-4020(96)00815-0

Reference yield: 80.0%

2-Hydroxy-4-methoxybenzaldehyde (673-22-3) + para-iodoanisole (696-62-8) → 2-hydroxy-4,4'-dimethoxybenzophenone (6131-38-0)

Guidance literature:

With dicarbonylacetylacetonato rhodium (I); sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 100 ℃; for 1h; Schlenk technique; Inert atmosphere;

DOI:10.1002/ejoc.201700881

Reference yield: 70.0%

bis(p-methoxyphenyl)methanone (90-96-0) → 2-hydroxy-4,4'-dimethoxybenzophenone (6131-38-0)

Guidance literature:

With palladium diacetate; bis-[(trifluoroacetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 80 ℃; for 2h;

DOI:10.1021/ol303088z

upstream raw materials:

4-methoxysalicylic acid

methoxybenzene

(2,4-dihydroxyphenyl)(4-methoxyphenyl)methanone

methyl iodide

Downstream raw materials:

4-[5-methoxy-2-(4-methoxybenzyl)phenoxy]phenol

Refernces

• 1、 Rao, Maddali L. N.,Ramakrishna, Boddu S.. "Rhodium-Catalyzed Directing-Group-Assisted Aldehydic C–H Arylations with Aryl Halides". . p. 5080 - 5093. Retrieved 2017/09/20.
• 2、 -. "SUNSCREEN COMPOSITIONS". . . Retrieved 2008/06/13.