7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Base Information

• Chemical Name: 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin
• CAS No.: 76877-33-3
• Molecular Formula: C24H22N2O4
• Molecular Weight: 402.4425
• UNII: DS09NL006S
• DSSTox Substance ID: DTXSID30227682
• Nikkaji Number: J575.625A
• Wikidata: Q27276571
• Pharos Ligand ID: FHF8XTKL2MW5
• ChEMBL ID: CHEMBL3416552
• Mol file: 76877-33-3.mol

Synonyms:3-(4-maleimidophenyl)-4-methyl-7-(diethylamino)coumarin;3-(4-maleimidylphenyl)-4-methyl-7-diethylamino coumarin;3-MMDAC;7-diethylamino-3-(4'-maleimidylphenyl)-4-methylcoumarin;CPM cpd;DEMCPM;N-(4-(7-diethylamino-4-methylcoumarin-3-yl)phenyl)maleimide

Chemical Property of 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin

Chemical Property:

• Vapor Pressure: 3.09E-15mmHg at 25°C
• Refractive Index: 1.648
• Boiling Point: 618.7 °C at 760 mmHg
• PKA: 3.28±0.20(Predicted)
• Flash Point: 328 °C
• PSA: 70.83000
• Density: 1.302 g/cm³
• LogP: 4.10900
• Storage Temp.: ?20°C
• Solubility.: DMSO: soluble
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 402.15795719
• Heavy Atom Count: 30
• Complexity: 756

Purity/Quality:

99% ^*data from raw suppliers

7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Dyes -> Coumarin Dyes
• Canonical SMILES: CCN(CC)C1=CC2=C(C=C1)C(=C(C(=O)O2)C3=CC=C(C=C3)N4C(=O)C=CC4=O)C
• Recent EU Clinical Trials: SIOP Ependymoma II - An International Clinical Program for the diagnosis and treatment of children, adolescents and young adults with Ependymoma
• Description: 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin is a thiol-reactive fluorescent probe. It displays excitation/emission maxima of 387/468 nm, respectively, and fluorescence intensity increases when bound to cysteine residues.
• Uses: (7-Diethylamino-3-(4'-maleimidylphenyl)-4- methylcoumarin)CPM is probably the most widely used blue fluorescent thiol-reactive dye. This maleimide derivative of coumarin is essentially nonfluorescent until it reacts with thiols, making it possible to quantify thiols without a separation step. CPM is a good energ 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin is a thiol-reactive fluorescent probe. 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM) is a thiol-reactive fluorescent probe. CPM selectively forms Michael adducts in the presence of hyperreactive sulfhydryls. CPM has been used to monitor the release of thiols, quantitate thiol in microplate reactions, and to distinguish proliferating cancer cells by nucleolar protein staining. Dyes and metabolites.