Technology Process of Quinoline, 1,2,3,4-tetrahydro-3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]-
There total 8 articles about Quinoline, 1,2,3,4-tetrahydro-3,3-dimethyl-1-[(4-methylphenyl)sulfonyl]- which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3,3-dimethyl-1,2-dihydro-1-p-tolylsulphonylquinolin-4(3H)-one;
With
hydrogenchloride; hydrazine hydrate;
In
diethylene glycol;
for 12h;
Reflux;
With
potassium hydroxide;
In
diethylene glycol;
for 15h;
Reflux;
DOI:10.1021/jacs.8b03187
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 65 percent / phophorus pentaoxide / xylene / 2 h / Heating
2: 1.) hydrazine hydrate, hydrazine dihydrochloride; 2,) potassium hydroxide / 1.) diethylene glycol, reflux, 12 h; 2.) 210 deg C, reflux, 12 h
With
potassium hydroxide; hydrazine dihydrochloride; phosphorus pentoxide; hydrazine hydrate;
In
xylene;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: thionyl chloride / tetrahydrofuran / 2 h / 90 °C / Reflux
1.2: 0.5 h / 0 °C
2.1: lithium aluminium tetrahydride / tetrahydrofuran / 18 h / Inert atmosphere; Reflux
3.1: pyridine / 4 h / 0 - 23 °C
4.1: sulfuric acid; acetic acid; water; sodium dichromate hydrate / 2 h / Reflux
5.1: phosphorus pentoxide / 5,5-dimethyl-1,3-cyclohexadiene / 2 h / Reflux
6.1: hydrogenchloride; hydrazine hydrate / diethylene glycol / 12 h / Reflux
6.2: 15 h / Reflux
With
pyridine; hydrogenchloride; lithium aluminium tetrahydride; thionyl chloride; sodium dichromate hydrate; phosphorus pentoxide; sulfuric acid; water; hydrazine hydrate; acetic acid;
In
tetrahydrofuran; 5,5-dimethyl-1,3-cyclohexadiene; diethylene glycol;
4.1: |Jones Oxidation / 5.1: |Friedel-Crafts Acylation / 6.1: |Wolff-Kishner Reduction / 6.2: |Wolff-Kishner Reduction;
DOI:10.1021/jacs.8b03187