6-(1H-pyrazol-1-yl)-2,2'-bipyridine

Base Information

• Chemical Name: 6-(1H-pyrazol-1-yl)-2,2'-bipyridine
• CAS No.: 135853-33-7
• Molecular Formula: C13H10N4
• Molecular Weight: 222.249
• Mol file: 135853-33-7.mol

Synonyms:pyridine-pyridine-pyrazole;6-(Pyrazol-1-yl)-2,2'-bipyridine;bipyridine-pyrazole;6-(N-pyrazolyl)-2,2'-bipyridine;

Chemical Property of 6-(1H-pyrazol-1-yl)-2,2'-bipyridine

Chemical Property:

• PSA: 43.60000
• LogP: 2.32930

Purity/Quality:

99%, ^*data from raw suppliers

2,2'-Bipyridine, 6-(1H-pyrazol-1-yl) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-(1H-pyrazol-1-yl)-2,2'-bipyridine

There total 4 articles about 6-(1H-pyrazol-1-yl)-2,2'-bipyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

NH-pyrazole (288-13-1) + 6-fluoro-2,2′-bipyridine (1223063-81-7) → 6-(1H-pyrazol-1-yl)-2,2'-bipyridine (135853-33-7)

Guidance literature:

NH-pyrazole; With sodium t-butanolate; In dimethyl sulfoxide; at 20 ℃; for 0.166667h; Inert atmosphere;

6-fluoro-2,2′-bipyridine; In dimethyl sulfoxide; at 100 ℃; for 24h;

Reference yield: 64.0%

NH-pyrazole (288-13-1) + 6-Chloro-[2,2']bipyridinyl (13040-77-2) → 6-(1H-pyrazol-1-yl)-2,2'-bipyridine (135853-33-7)

Guidance literature:

With potassium; In diethylene glycol dimethyl ether; at 130 ℃; for 168h;

DOI:10.1071/C99029

Reference yield:

pyridin-2-ylzinc(II) bromide → 6-(1H-pyrazol-1-yl)-2,2'-bipyridine (135853-33-7)

Guidance literature:

Multi-step reaction with 2 steps

1.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran / 20 °C / Inert atmosphere

2.1: sodium t-butanolate / dimethyl sulfoxide / 0.17 h / 20 °C / Inert atmosphere

2.2: 24 h / 100 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium t-butanolate; In tetrahydrofuran; dimethyl sulfoxide;

upstream raw materials:

NH-pyrazole

6-Chloro-[2,2']bipyridinyl

2-bromo-6-fluoropyridine

6-fluoro-2,2′-bipyridine

Refernces

• 1、 -. "Improved redox couple for electrochemical and optoelectronic devices". Page/Page column 22. . Retrieved 2012/09/10.
• 2、 Baker, Anthony T.,Matthews, Jeremy P.. "Iron (II) and nickel (II) complexes of 6-(pyrazol-l-yl)-2,2′-bipyridine". . p. 339 - 342. Retrieved 2007/10/03.