2-PIPERIDINOANILINE

Base Information

• Chemical Name: 2-PIPERIDINOANILINE
• CAS No.: 39643-31-7
• Molecular Formula: C11H16 N2
• Molecular Weight: 176.261
• Hs Code.: 29333999
• Mol file: 39643-31-7.mol

Synonyms:Piperidine,1-(o-aminophenyl)- (6CI); 1-(2-Aminophenyl)piperidine;2-(Piperidin-1-yl)benzenamine; 2-Piperidinoaniline; N-(2-Aminophenyl)piperidine;o-Piperidinoaniline

Chemical Property of 2-PIPERIDINOANILINE

Chemical Property:

• Appearance/Colour: brown crystals or crystalline powder
• Vapor Pressure: 0.000509mmHg at 25°C
• Melting Point: 44-48 °C
• Boiling Point: 96 °C (1 mmHg)
• PKA: 7.03±0.10(Predicted)
• Flash Point: 125.8°C
• PSA: 29.26000
• Density: 1.074g/cm³
• LogP: 2.90530
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility.: DMSO (Slightly), Methanol (Slightly)

Purity/Quality:

99% ^*data from raw suppliers

2-(1-Piperidino)aniline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,T,Xi
• Hazard Codes: Xn,T,Xi
• Statements: 20/21/22-36
• Safety Statements: 36/37

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-(1-Piperidino)aniline is used to prepare oxalylarylaminobenzoic acids as inhibitors of protein tyrosine phosphatase 1B. It is also used to synthesize benzimidazole derivatives as AMP-activated protein kinase activators.

Technology Process of 2-PIPERIDINOANILINE

There total 8 articles about 2-PIPERIDINOANILINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-(2-nitrophenyl)piperidine (15822-77-2) → 2-piperidin-1-yl-phenylamine (39643-31-7)

Guidance literature:

With 5%-palladium/activated carbon; hydrogen; In methanol; at 20 ℃; for 14h; under 1500.15 Torr; Inert atmosphere;

DOI:10.1002/hlca.201600165

Reference yield: 52.0%

1,2,3,4-tetrahydro-pyrido[1,2-a]benzimidazole (5622-83-3) → 2-piperidin-1-yl-phenylamine (39643-31-7) + 2,3,4,5,6,7-hexahydro-1H-benzo[b][1,4]diazonine (49809-51-0)

Guidance literature:

1,2,3,4-tetrahydro-pyrido[1,2-a]benzimidazole; With diisobutylaluminium hydride; In toluene; at 0 ℃; for 23h; Inert atmosphere; Reflux;

With water; sodium fluoride; In toluene; benzene; at 0 - 20 ℃; for 0.333333h; regioselective reaction; Inert atmosphere;

DOI:10.1016/j.tetlet.2013.11.025

Reference yield:

piperidine (110-89-4) → 2-piperidin-1-yl-phenylamine (39643-31-7)

Guidance literature:

Multi-step reaction with 2 steps

2: platinum; methanol / Hydrogenation

With methanol; platinum;

upstream raw materials:

1-(2-nitrophenyl)piperidine

2,2'-dipiperidino-azoxybenzene

piperidine

2-Chloronitrobenzene

Downstream raw materials:

5-phenylamino-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide

5-bromo-furan-2-carboxylic acid (2-piperidin-1-yl-phenyl)-amide

Refernces

• 1、 Li, An,Li, Caohui,Li, Lijun,Liu, Yu,Tang, Kewen,Yang, Tao,Yang, Zan,Zhou, Congshan. "Electrochemical Synthesis of Benzo[ d]imidazole via Intramolecular C(sp3)-H Amination". . . Retrieved 2022/01/03.
• 2、 Di Franco, Thomas,Stojanovic, Marko,Keller, Sébastien Carlos,Scopelliti, Rosario,Hu, Xile. "A Structure–Activity Study of Nickel NNN Pincer Complexes for Alkyl-Alkyl Kumada and Suzuki–Miyaura Coupling Reactions". . p. 830 - 847. Retrieved 2016/11/11.