1-(2-NITROPHENYL)PIPERIDINE

Base Information

• Chemical Name: 1-(2-NITROPHENYL)PIPERIDINE
• CAS No.: 15822-77-2
• Molecular Formula: C11H14N2O2
• Molecular Weight: 206.244
• Hs Code.: 2933399090
• Mol file: 15822-77-2.mol

Synonyms:Piperidine,1-(o-nitrophenyl)- (8CI);1-(2-Nitrophenyl)piperidine;2-(Piperidino)-1-nitrobenzene;2-Piperidinonitrobenzene;N-(2-Nitrophenyl)piperidine;NSC 14848;o-Nitropiperidinobenzene;

Chemical Property of 1-(2-NITROPHENYL)PIPERIDINE

Chemical Property:

• Vapor Pressure: 0.000103mmHg at 25°C
• Melting Point: 77-79 °C
• Refractive Index: 1.578
• Boiling Point: 337.7 °C at 760 mmHg
• Flash Point: 158 °C
• PSA: 49.06000
• Density: 1.188 g/cm³
• LogP: 3.17330

Purity/Quality:

99% ^*data from raw suppliers

1-(2-Nitrophenyl)piperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39-37

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Uses: 1-(2-Nitrophenyl)piperidine is used to prepare butylbenzyl methylsulfonyl aminophenyl propanamide TRPV1 antagonists as potential analgesics. It is also used to synthesize (methylsulfonylamino)benzenes as vanilloid antagonists showing excellent analgesic activity.

Technology Process of 1-(2-NITROPHENYL)PIPERIDINE

There total 21 articles about 1-(2-NITROPHENYL)PIPERIDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

piperidine (110-89-4) + ortho-nitrofluorobenzene (1493-27-2,127723-77-7) → 1-(2-nitrophenyl)piperidine (15822-77-2)

Guidance literature:

In toluene; at 25 ℃;

Reference yield: 96.0%

piperidine (110-89-4) + 2-nitrophenyl bromide (577-19-5) → 1-(2-nitrophenyl)piperidine (15822-77-2)

Guidance literature:

With L-2-O-methyl-chiro-inositol; copper(II) acetate monohydrate; potassium carbonate; In dimethyl sulfoxide; at 110 ℃; for 12h; Inert atmosphere;

DOI:10.1055/s-0039-1690707

Reference yield: 92.0%

piperidine (110-89-4) + 2-Chloronitrobenzene (88-73-3) → 1-(2-nitrophenyl)piperidine (15822-77-2)

Guidance literature:

With solid-supported nano and microparticles of Pd⁽⁰⁾; In N,N-dimethyl-formamide; at 80 ℃; for 6h;

DOI:10.1016/j.tetlet.2012.07.096

upstream raw materials:

piperidine

1-nitro-2-tosylbenzene

2-nitrophenyl bromide

(4-methyl-2-nitro-phenyl)-(2-nitro-phenyl)-ether

Downstream raw materials:

2-piperidin-1-yl-phenylamine

1-(2-nitrophenyl)piperidine-2-carbonitrile

1,2,3,4-tetrahydro-pyrido[1,2-a]benzimidazole

6,6a,7,8,9,10-hexahydro-5H-pyrido[1,2-a]quinoxaline

Refernces

• 1、 Du, Shijie,Lu, Huizhe,Yang, Dongyan,Li, Hong,Gu, Xilin,Wan, Chuan,Jia, Changqing,Wang, Mian,Li, Xiuyun,Qin, Zhaohai. "Synthesis, antifungal activity and QSAR of some novel carboxylic acid amides". . p. 4071 - 4087. Retrieved 2015.
• 2、 Bailey, Brodie L.,Nguyen, William,Ngo, Anna,Goodman, Christopher D.,Gancheva, Maria R.,Favuzza, Paola,Sanz, Laura M.,Gamo, Francisco-Javier,Lowes, Kym N.,McFadden, Geoffrey I.,Wilson, Danny W.,Laleu, Beno?t,Brand, Stephen,Jackson, Paul F.,Cowman, Alan F.,Sleebs, Brad E.. "Optimisation of 2-(N-phenyl carboxamide) triazolopyrimidine antimalarials with moderate to slow acting erythrocytic stage activity". . . Retrieved 2021/08/30.
• 3、 Joshi, Raj Kumar,Sharma, Charu,Sharma, Kamal Nayan,Srivastava, Avinash Kumar. "Half-sandwich (η5-Cp?)Rh(iii) complexes of pyrazolated organo-sulfur/selenium/tellurium ligands: Efficient catalysts for base/solvent free C-N coupling of chloroarenes under aerobic conditions". supporting information. p. 3599 - 3606. Retrieved 2020/06/10.