N-(2-Bromo-phenyl)-2-chloro-acetamide

Base Information

• Chemical Name: N-(2-Bromo-phenyl)-2-chloro-acetamide
• CAS No.: 6090-78-4
• Molecular Formula: C8H7 Br Cl N O
• Molecular Weight: 248.507
• Hs Code.: 2924299090
• Mol file: 6090-78-4.mol

Synonyms:Acetanilide,2'-bromo-2-chloro- (8CI)

Chemical Property of N-(2-Bromo-phenyl)-2-chloro-acetamide

Chemical Property:

• Vapor Pressure: 9.54E-07mmHg at 25°C
• Boiling Point: 404.3°C at 760 mmHg
• Flash Point: 198.3°C
• PSA: 29.10000
• Density: 1.486g/cm³
• LogP: 2.69940

Purity/Quality:

98%,99%, ^*data from raw suppliers

N-(2-Bromophenyl)-2-chloroacetamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(2-Bromo-phenyl)-2-chloro-acetamide

There total 1 articles about N-(2-Bromo-phenyl)-2-chloro-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 47.0%

chloroacetyl chloride (79-04-9) + 2-bromoaniline (615-36-1) → N-(2-bromophenyl)-2-chloroacetamide (6090-78-4)

Guidance literature:

With sodium hydroxide; In water;

DOI:10.1016/j.tetlet.2006.06.090

Reference yield: 92.0%

6-chloro-1-(3,5-dimethylbenzyl)-1,3-dihydro-2H-benzimidazole-2-thione (1061732-18-0) + N-(2-bromophenyl)-2-chloroacetamide (6090-78-4) → 2-{[6-chloro-1-(3,5-dimethylbenzyl)-1H-benzimidazol-2-yl]sulfanyl}-N-2-bromophenylacetamide (1562664-93-0)

Guidance literature:

With potassium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 1h;

DOI:10.1016/j.bmc.2013.12.045

Reference yield: 89.0%

N-(2-bromophenyl)-2-chloroacetamide (6090-78-4) + 2-nitro-benzaldehyde (552-89-6) → trans-N-(2-bromophenyl)-3-(2-nitrophenyl)oxirane-2-carboxamide

Guidance literature:

With sodium methylate; In methanol; at 20 ℃;

DOI:10.1016/j.tetlet.2019.151205

upstream raw materials:

chloroacetyl chloride

2-bromoaniline

Downstream raw materials:

N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

N-(2-Bromo-phenyl)-2-(2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

2-(7-Benzyloxy-2,2-dimethyl-4-oxo-chroman-6-yloxy)-N-(2-bromo-phenyl)-acetamide

Refernces

• 1、 Mohammadi-Khanaposhtani, Maryam,Nikraftar, Atefeh,Asgari, Mohammad Sadegh,Emadi, Mehdi,Mojtabavi, Somayeh,Faramarzi, Mohammad Ali,Rastegar, Hossein,Larijani, Bagher,Mahdavi, Mohammad. "Synthesis, in vitro and in silico enzymatic inhibition assays, and toxicity evaluations of new 4,5-diphenylimidazole-N-phenylacetamide derivatives as potent α-glucosidase inhibitors". . p. 1273 - 1283. Retrieved 2021/05/26.
• 2、 Chakravarty, Harapriya,Ju, Yaojun,Chen, Wen-Hua,Tam, Kin Y.. "Dual targeting of cholinesterase and amyloid beta with pyridinium/isoquinolium derivatives". . p. 242 - 255. Retrieved 2019/12/27.