N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

Base Information

• Chemical Name: N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide
• CAS No.: 133035-53-7
• Molecular Formula: C₂₀H₂₀BrNO₅
• Molecular Weight: 434.286
• Mol file: 133035-53-7.mol

Synonyms:N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

Chemical Property of N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide

There total 4 articles about N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.3%

2,3-dihydro-7-hydroxy-6-methoxy-2,2-dimethyl-4H-1-benzopyran-4-one (74094-45-4) + N-(2-bromophenyl)-2-chloroacetamide (6090-78-4) → N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide (133035-53-7)

Guidance literature:

With potassium carbonate; sodium iodide; In acetone; for 6h; Heating;

Reference yield:

2,2-Dimethyl-6,7-dihydroxy-4-chromanone (76348-95-3) → N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide (133035-53-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 63.3 percent / K₂CO₃, NaI / acetone / 6 h / Heating

2: 64.5 percent / K₂CO₃ / acetone / 2 h / Heating

3: 95.4 percent / H₂ / 10percent Pd/C / acetone

4: 75.3 percent / K₂CO₃, NaI / acetone / 6 h / Heating

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In acetone;

Reference yield:

7-Benzyloxy-2,2-dimethyl-6-methoxy-4-chromanone (125627-99-8) → N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-4-oxo-chroman-7-yloxy)-acetamide (133035-53-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 95.4 percent / H₂ / 10percent Pd/C / acetone

2: 75.3 percent / K₂CO₃, NaI / acetone / 6 h / Heating

With hydrogen; potassium carbonate; sodium iodide; palladium on activated charcoal; In acetone;

upstream raw materials:

2,3-dihydro-7-hydroxy-6-methoxy-2,2-dimethyl-4H-1-benzopyran-4-one

N-(2-bromophenyl)-2-chloroacetamide

2,2-Dimethyl-6,7-dihydroxy-4-chromanone

7-Benzyloxy-2,2-dimethyl-6-methoxy-4-chromanone

Downstream raw materials:

N-(2-Bromo-phenyl)-2-(6-methoxy-2,2-dimethyl-2H-chromen-7-yloxy)-acetamide

N-(2-Bromo-phenyl)-2-(4-hydroxy-6-methoxy-2,2-dimethyl-chroman-7-yloxy)-acetamide

Refernces