Edrophonium chloride

Base Information

• Chemical Name: Edrophonium chloride
• CAS No.: 116-38-1
• Molecular Formula: C10H16 N O . Cl
• Molecular Weight: 201.696
• Hs Code.: 2923900100
• European Community (EC) Number: 204-138-4
• NSC Number: 759577
• UNII: QO611KSM5P
• DSSTox Substance ID: DTXSID1022978
• Wikidata: Q27068168
• NCI Thesaurus Code: C47507
• Pharos Ligand ID: 3AWUANBKHGR9
• Metabolomics Workbench ID: 49996
• ChEMBL ID: CHEMBL1128
• Mol file: 116-38-1.mol

Synonyms:Bromide, Edrophonium;Chloride, Edrophonium;Edrophonium;Edrophonium Bromide;Edrophonium Chloride;Edroponium;Tensilon

Chemical Property of Edrophonium chloride

Chemical Property:

• Appearance/Colour: White powder
• Melting Point: 162-163 °C (decomp)
• Refractive Index: 1.6000 (estimate)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• PSA: 20.23000
• Density: g/cm³
• LogP: -1.01700
• Storage Temp.: Inert atmosphere,Room Temperature
• Solubility.: Very soluble in water, freely soluble in ethanol (96 per cent), practically insoluble in methylene chloride.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 201.0920418
• Heavy Atom Count: 13
• Complexity: 145

Purity/Quality:

98% ^*data from raw suppliers

Edrophonium Chloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC[N+](C)(C)C1=CC(=CC=C1)O.[Cl-]
• Uses: A reversible Acetylcholinesterase inhibitor. Myasthenia Gravis test;Cholinergic Edrophonium (chloride) is an acetylcholinesterase (AChE) inhibitor that is known to prevent the breakdown of the neurotransmitter acetylcholine by binding specifically to its catalytic site. It has been shown to inhibit AChE activity in human red blood cells, purified calf forebrain, and purified octopus brain with Ki values of 0.2, 0.2, and 0.4 μM, respectively. Edrophonium is often used as part of a battery of pharmacological tests to confirm a diagnosis of the autoimmune neuromuscular junction disorder, myasthenia gravis.
• Therapeutic Function: Cholinergic (ophthalmic)
• Clinical Use: Edrophonium Chloride is also used to terminate the action of any one ofthese drugs when the physician so desires. It is of no value,however, in terminating the action of the depolarizing (i.e.,noncompetitive) blocking agents, such as decamethoniumand succinylcholine. In addition to inhibiting AChE, edrophoniumchloride has a direct cholinomimetic effect onskeletal muscle, which is greater than that of most otheranticholinesterase drugs.

Technology Process of Edrophonium chloride

There total 2 articles about Edrophonium chloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl iodide (75-03-6) + 3-Dimethylaminophenol (99-07-0) → edrophonium chloride (116-38-1)

Guidance literature:

Reference yield:

ethyl bromide (74-96-4) + 3-Dimethylaminophenol (99-07-0) → edrophonium chloride (116-38-1)

Guidance literature:

Reference yield:

edrophonium chloride (116-38-1) + [11C]methyl triflate (145577-00-0) → [11C]methyl-edrophonium

Guidance literature:

With sodium hydrogencarbonate; In dichloromethane; acetonitrile; at 70 - 80 ℃;

upstream raw materials:

ethyl iodide

3-Dimethylaminophenol

ethyl bromide