CAS No.116-38-1,Edrophonium chloride Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	116-38-1
Name:	Edrophonium chloride

Formula:	C10H16 N O . Cl
Molecular Weight:	201.696
Synonyms:	Ammonium,ethyl(m-hydroxyphenyl)dimethyl-, chloride (8CI); Benzenaminium,N-ethyl-3-hydroxy-N,N-dimethyl-, chloride (9CI);Ethyl(m-hydroxyphenyl)dimethylammonium chloride (6CI,7CI); Antirex;Dimethylethyl(3-hydroxyphenyl)ammonium chloride; Edrophonium chloride; Enlon;Ethyl(3-hydroxyphenyl)dimethylammonium chloride; Reversol; Tensilon; Tensilon chloride
EINECS:	204-138-4
Density:	g/cm³
Melting Point:	162-163 °C (decomp)
Boiling Point:	°Cat760mmHg
Flash Point:	°C
Solubility:	Soluble in water (50mg/ml)
Appearance:	White powder
Safety:	Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cl⁻, NH₃, and NO_x. See also CHLORIDES.
PSA:	20.23000
LogP:	-1.01700

Synthetic route

: 75-03-6
ethyl iodide

: 99-07-0
3-Dimethylaminophenol

: 116-38-1
edrophonium chloride

: 74-96-4
ethyl bromide

: 99-07-0
3-Dimethylaminophenol

: 116-38-1
edrophonium chloride

: 116-38-1
edrophonium chloride

: 145577-00-0
[11C]methyl triflate

: [11C]methyl-edrophonium

Conditions

Conditions	Yield
With sodium hydrogencarbonate In dichloromethane; acetonitrile at 70 - 80℃;

Raw Materials

74-96-4

75-03-6

99-07-0

Total:82 Page 1 of 3 1 2 3 Next>>

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Chemistry

IUPAC Name: Ethyl-(3-hydroxyphenyl)-dimethylazanium chloride
The MF of Edrophonium chloride (CAS NO.116-38-1) is C₁₀H₁₆ClNO.

The MW of Edrophonium chloride (CAS NO.116-38-1) is 201.69.
Synonyms of Edrophonium chloride (CAS NO.116-38-1): Antirex ; Dimethylethyl(M-hydroxyphenyl)-ammoniuchloride ; Ethyl(M-hydroxyphenyl)dimethyl-ammoniuchloride ; N-ethyl-3-hydroxy-N,N-dimethyl-benzenaminiuchloride ; Tensilon ; Ethyl(3-hydroxyphenyl)dimethylammonium chloride
EINECS: 204-138-4

Uses

Edrophonium chloride (CAS NO.116-38-1) prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction.It is used to differentiate myasthenic crisis from cholinergic crisis.

Toxicity Data With Reference

1.	ipr-mus LD50:30 mg/kg	PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. 10 (1976),327.
2.	scu-mus LD50:52 mg/kg	JPETAB Journal of Pharmacology and Experimental Therapeutics. 123 (1958),121.
3.	ivn-mus LD50:15 mg/kg	NIIRDN “Drugs in Japan. Ethical Drugs, 6th Edition 1982“ Edited by Japan Pharmaceutical Information Center. 6 (1982),133.

Safety Profile

Poison by subcutaneous, intravenous, and intraperitoneal routes. When heated to decomposition it emits toxic fumes of Cl⁻, NH₃, and NO_x. See also CHLORIDES.Safety information of Edrophonium chloride (CAS NO.116-38-1):
WGK Germany 3
RTECS BQ5870000

Specification

Edrophonium is a readily reversible acetylcholinesterase inhibitor. It prevents breakdown of the neurotransmitter acetylcholine and acts by competitively inhibiting the enzyme acetylcholinesterase, mainly at the neuromuscular junction. It is sold under the trade names Tensilon, Enlon and Reversol.