Chlorambucyl-proline

Base Information

• Chemical Name: Chlorambucyl-proline
• CAS No.: 81050-71-7
• Molecular Formula: C₁₉H₂₆Cl₂N₂O₃
• Molecular Weight: 401.333
• Mol file: 81050-71-7.mol

Synonyms:

Chemical Property of Chlorambucyl-proline

Chemical Property:

• Vapor Pressure: 4.76E-16mmHg at 25°C
• Boiling Point: 616.3°Cat760mmHg
• Flash Point: 326.6°C
• Density: 1.291g/cm³

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Chlorambucyl-proline

There total 3 articles about Chlorambucyl-proline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

N-[4-[4-(N,N-bis(2-chloroethyl)amino)phenyl]butyryl]-L-proline benzyl ester → N-[4-[4-(N,N-bis(2-chloroethyl)amino)phenyl]butyryl]-L-proline (81050-71-7)

Guidance literature:

With hydrogen; palladium on activated charcoal; In ethanol; at 20 ℃; for 6h;

Reference yield:

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride (16652-71-4) → N-[4-[4-(N,N-bis(2-chloroethyl)amino)phenyl]butyryl]-L-proline (81050-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NEt₃; N,N'-dicyclohexylcarbodiimide / CHCl₃ / 26 h / 0 - 20 °C

2: 74 percent / H₂ / 10 percent Pd/C / ethanol / 6 h / 20 °C

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; chloroform;

Reference yield:

chlorambucil (305-03-3) → N-[4-[4-(N,N-bis(2-chloroethyl)amino)phenyl]butyryl]-L-proline (81050-71-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 76 percent / NEt₃; N,N'-dicyclohexylcarbodiimide / CHCl₃ / 26 h / 0 - 20 °C

2: 74 percent / H₂ / 10 percent Pd/C / ethanol / 6 h / 20 °C

With hydrogen; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In ethanol; chloroform;

upstream raw materials:

benzyl (2S)-2-pyrrolidinecarboxylate hydrochloride

chlorambucil

Refernces