Chlorambucil

Base Information Edit

Chemical Name:Chlorambucil
CAS No.:305-03-3
Molecular Formula:C14H19Cl2NO2
Molecular Weight:304.216
Hs Code.:2922499990
European Community (EC) Number:206-162-0
NSC Number:756674,3088
UN Number:2811
UNII:18D0SL7309
DSSTox Substance ID:DTXSID7020263
Nikkaji Number:J1.521K
Wikipedia:Chlorambucil
Wikidata:Q415939
NCI Thesaurus Code:C362
RXCUI:2346
Metabolomics Workbench ID:42680
ChEMBL ID:CHEMBL515
Mol file:305-03-3.mol

Synonyms:4-(Bis(2-chloroethyl)amino)benzenebutanoic Acid;Amboclorin;CB 1348;CB-1348;CB1348;Chlorambucil;Chloraminophene;Chlorbutin;Leukeran;Lympholysin;N,N-Di-(2-chloroethyl)-p-aminophenylbutyric Acid;NSC 3088;NSC-3088;NSC3088

Suppliers and Price of Chlorambucil

Supply Marketing:Edit

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 144 raw suppliers

Chemical Property of Chlorambucil Edit

Chemical Property:

Appearance/Colour:beige powder
Vapor Pressure:2.98E-09mmHg at 25°C
Melting Point:65-70 °C
Refractive Index:1.536
Boiling Point:460.09 °C at 760 mmHg
Flash Point:232.054 °C
PSA：40.54000
Density:1.248 g/cm³
LogP:3.37790
Water Solubility.:<0.01 g/100 mL at 22℃
XLogP3:1.7
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:9
Exact Mass:303.0792842
Heavy Atom Count:19
Complexity:250
Transport DOT Label:Poison

Purity/Quality:: 99%（min） ^*data from raw suppliers

Safty Information:

Pictogram(s): T
Hazard Codes: T:Toxic;
Statements: R45:; R25:; R36/37/38:;
Safety Statements: S53:; S26:; S45:;

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Drug Classes:Antineoplastic Agents, Alkylating
Canonical SMILES:C1=CC(=CC=C1CCCC(=O)O)N(CCCl)CCCl
Recent ClinicalTrials:Phase II Study of Chlorambucil and Subcutaneous Rituximab in Patients With Extranodal MALT Lymphoma
Recent EU Clinical Trials:A pilot study of chlorambucil in pre-treated metastatic pancreatic adenocarcinoma patients bearing a germ line BRCA or other DNA Defects Repair (DDR) mutations.

Technology Process of Chlorambucil

There total 63 articles about Chlorambucil which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.9%

: 2033-24-1
cycl-isopropylidene malonate

: 500590-36-3
2-(4-(N,N-bis(2-chloroethyl)amino)phenyl)acetaldehyde

: 305-03-3
chlorambucil

Guidance literature:: With formic acid; triethylamine; at 50 - 95 ℃; for 5h; Temperature;

Reference yield: 54.0%

: 4-(4-(bis(2-chloroethyl)amino)phenyl)-4-oxobutanoic acid

: 305-03-3
chlorambucil

Guidance literature:: With formic acid; 1,1,1,3',3',3'-hexafluoro-propanol; water; at 80 ℃; for 2h; chemoselective reaction; Sealed tube;
DOI:10.1002/adsc.202000821