8-CHLOROQUINALDINE

Base Information

• Chemical Name: 8-CHLOROQUINALDINE
• CAS No.: 3033-82-7
• Molecular Formula: C10H8ClN
• Molecular Weight: 177.633
• Hs Code.: 2933499090
• Mol file: 3033-82-7.mol

Synonyms:Quinaldine,8-chloro- (6CI,7CI,8CI);8-Chloro-2-methylquinoline;NSC4982;

Chemical Property of 8-CHLOROQUINALDINE

Chemical Property:

• Appearance/Colour: white to light yellow crystal powder
• Vapor Pressure: 0.00732mmHg at 25°C
• Melting Point: 64 °C
• Refractive Index: 1.634
• Boiling Point: 278.177 °C at 760 mmHg
• PKA: 3.17±0.50(Predicted)
• Flash Point: 148.736 °C
• PSA: 12.89000
• Density: 1.225 g/cm³
• LogP: 3.19660
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

8-Chloroquinaldine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi,Xn
• Hazard Codes: Xi,Xn
• Statements: 36/37/38-41-37/38-22
• Safety Statements: 26-36/37/39-37/39

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 8-CHLOROQUINALDINE

There total 11 articles about 8-CHLOROQUINALDINE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

trans-Crotonaldehyde (123-73-9,4170-30-3) + o-chloroaniline (95-51-2) → 8-chloroquinaldine (3033-82-7)

Guidance literature:

With phospho-tungstic acid; phosphotungstic acid; silica gel; for 0.216667h; microwave irradiation;

DOI:10.1016/j.tetlet.2006.01.034

Reference yield: 72.0%

ethylene glycol (107-21-1) + o-chloroaniline (95-51-2) → 8-chloroquinaldine (3033-82-7)

Guidance literature:

With tetrachloromethane; iron(III) chloride hexahydrate; at 150 ℃; for 8h; Inert atmosphere; Sealed tube; Autoclave;

DOI:10.1002/jhet.2425

Reference yield: 64.0%

8-chloro-2-methyl-1,2,3,4-tetrahydroquinoline (1298100-95-4) → 8-chloroquinaldine (3033-82-7)

Guidance literature:

With oxygen; iron(II) chloride; In para-xylene; dimethyl sulfoxide; at 110 ℃; for 40h; Schlenk technique;

DOI:10.1055/s-0035-1561613

upstream raw materials:

ethylene glycol

o-chloroaniline

acetaldehyde

acetylene

Downstream raw materials:

2-methyl-8-(diphenylphosphino)quinoline

8-(methylphenylphosphanyl)quinoline

2-methyl-8-quinolineboronic acid

potassium (2-methylquinolin-8-yl)trifluoroborate

Refernces

• 1、 Zhou, Weiyou,Taboonpong, Piyada,Aboo, Ahmed Hamdoon,Zhang, Lingjuan,Jiang, Jun,Xiao, Jianliang. "A Convenient Procedure for the Oxidative Dehydrogenation of N-Heterocycles Catalyzed by FeCl2/DMSO". supporting information. p. 1806 - 1809. Retrieved 2016/07/16.
• 2、 Cui, Xinjiang,Li, Yuehui,Bachmann, Stephan,Scalone, Michelangelo,Surkus, Annette-Enrica,Junge, Kathrin,Topf, Christoph,Beller, Matthias. "Synthesis and Characterization of Iron-Nitrogen-Doped Graphene/Core-Shell Catalysts: Efficient Oxidative Dehydrogenation of N-Heterocycles". supporting information. p. 10652 - 10658. Retrieved 2015/09/28.