4-METHYLQUINOLIN-2-THIONE

Base Information

• Chemical Name: 4-METHYLQUINOLIN-2-THIONE
• CAS No.: 4437-65-4
• Molecular Formula: C10H9NS
• Molecular Weight: 175.254
• Hs Code.: 2933499090
• Mol file: 4437-65-4.mol

Synonyms:4-methylquinoline-2-thiolate;4-Methylquinoline-2-thiol;

Chemical Property of 4-METHYLQUINOLIN-2-THIONE

Chemical Property:

• Vapor Pressure: 0.00614mmHg at 25°C
• Melting Point: ca 255℃
• Refractive Index: 1.675
• Boiling Point: 272.3 °C at 760 mmHg
• PKA: 10.56±0.40(Predicted)
• Flash Point: 118.5 °C
• PSA: 51.69000
• Density: 1.22 g/cm³
• LogP: 2.83190
• Storage Temp.: 2-8°C

Purity/Quality:

99%, ^*data from raw suppliers

4-Methylquinoline-2-thiol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Methylquinoline-2-thiol is used in method using lifespan-altering compounds for altering lifespan of eukaryotic organisms, and screening for such compounds.

Technology Process of 4-METHYLQUINOLIN-2-THIONE

There total 10 articles about 4-METHYLQUINOLIN-2-THIONE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-tert-Butylsulfanyl-4-methyl-quinoline → 4-methyl-2-thioxo-1H-quinoline (4437-65-4)

Guidance literature:

Heating;

Reference yield: 85.0%

carbon disulfide (75-15-0,12122-00-8) + 2-isopropenylaniline (52562-19-3) → 4-methyl-2-thioxo-1H-quinoline (4437-65-4)

Guidance literature:

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In N,N-dimethyl-formamide; at 140 ℃; for 8h; Inert atmosphere;

DOI:10.1039/c7cc07633a

Reference yield: 74.0%

2-chloro-4-methylquinoline (634-47-9) → 2-mercapto-4-methylquinoline (4437-65-4)

Guidance literature:

With hydrogenchloride; sodium sulfide; In ethanol; for 4h; Reflux;

DOI:10.1007/s00044-017-1831-z

upstream raw materials:

2-chloro-4-methylquinoline

thiourea

4-methyl-1,2-dihydroquinolin-2-one

carbon disulfide

Downstream raw materials:

2-benzylmercapto-4-methyl-quinoline

2-ethylsulfanyl-4-methyl-quinoline

(4-methyl-2-quinolylthio)acetic acid

2-isopropylmercapto-4-methyl-quinoline

Refernces

• 1、 Sudhamani, Chittanahalli N.,Bhojya Naik, Halehatty S.,Gowda, Kalligundi R. Sangeetha,Giridhar, Manju,Girija, Dugganna,Kumar, Pasupanetti N. Prashanth. "Novel iron phenanthroline-based photosensitizers for antimicrobial PDT: synthesis, DNA binding and photo-induced DNA cleavage activity". . p. 1160 - 1169. Retrieved 2017.
• 2、 Wang, Tong-Lin,Liu, Xiao-Jun,Huo, Cong-De,Wang, Xi-Cun,Quan, Zheng-Jun. "Base-catalyzed thio-lactamization of 2-(1-arylvinyl)anilines with CS2 for the synthesis of quinoline-2-thiones". supporting information. p. 499 - 502. Retrieved 2018/01/19.