Acetic acid, 2-acetyl-1-phenylhydrazide

Base Information

• Chemical Name: Acetic acid, 2-acetyl-1-phenylhydrazide
• CAS No.: 38604-74-9
• Molecular Formula: C10H12N2O2
• Molecular Weight: 192.217
• Mol file: 38604-74-9.mol

Synonyms:

Chemical Property of Acetic acid, 2-acetyl-1-phenylhydrazide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Acetic acid, 2-acetyl-1-phenylhydrazide

There total 32 articles about Acetic acid, 2-acetyl-1-phenylhydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

1-acetyl-2-phenylhydrazine (114-83-0) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In neat (no solvent); at 40 ℃; for 2.5h; Sealed tube;

DOI:10.1021/acs.joc.7b01215

Reference yield: 79.0%

acetonitrile (75-05-8,26809-02-9) + 1-acetyl-2-phenylhydrazine (114-83-0) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9) + Acetanilid (103-84-4)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In neat (no solvent); at 40 ℃; for 2h; Sealed tube;

DOI:10.1021/acs.joc.7b01215

Reference yield: 78.0%

4-methoxybenzonitrile (874-90-8) + 1-acetyl-2-phenylhydrazine (114-83-0) → N'-acetyl-N'-phenylacetohydrazide (38604-74-9) + 4-methoxy-N-phenylbenzamide (7465-88-5)

Guidance literature:

With bis-[(trifluoroacetoxy)iodo]benzene; In neat (no solvent); at 40 ℃; for 3h; Temperature; Reagent/catalyst; Solvent; Sealed tube;

DOI:10.1021/acs.joc.7b01215

upstream raw materials:

pyridine

acetic anhydride

1-acetyl-2-phenylhydrazine

acetone phenylhydrazone

Downstream raw materials:

N,N'-diacetyl-N-methyl-N'-phenyl-hydrazine

1-acetyl-1-methyl-2-phenylhydrazine

1-Acetyl-1-phenylhydrazin

1-acetyl-2-phenylhydrazine

Refernces

• 1、 Hearn, Michael J.,Magee, Debra J.,Alhart, Randi,Gleva, Marye,Goldstein, Susan,et al.. "Acylation Reactions of Phenylhydrazines. Preparation and Properties of New Diacylphenylhydrazines". . p. 129 - 131. Retrieved 2007/10/02.