Dihydromorphine hydrochloride

Base Information

• Chemical Name: Dihydromorphine hydrochloride
• CAS No.: 1421-28-9
• Molecular Formula: C17H21 N O3 . Cl H
• Molecular Weight: 323.82
• UNII: 3T8C8KE0AW
• DSSTox Substance ID: DTXSID70931337
• Wikidata: Q27258007
• ChEMBL ID: CHEMBL543073
• Mol file: 1421-28-9.mol

Synonyms:Dihydromorphine hydrochloride;Dialudid;Morphine, dihydro-, hydrochloride;UNII-3T8C8KE0AW;NSC 404353;3T8C8KE0AW;Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, hydrochloride, (5-alpha,6-alpha)-;1421-28-9;Morphinan-3,6alpha-diol, 4,5-alpha-epoxy-17-methyl-, hydrochloride;Morphinan-3,6alpha-diol, 4,5alpha-epoxy-17-methyl-, hydrochloride;Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, hydrochloride, (5alpha,6alpha)-;Morphinan-3,6.alpha.-diol, 4,5.alpha.-epoxy-17-methyl-, hydrochloride;Morphinan-3,6-diol, 4,5-epoxy-17-methyl-, hydrochloride, (5.alpha.,6.alpha.)-;OC1CCC2C3Cc4ccc(O)c5OC1C2(CCN3C)c45;NSC-404353;CHEMBL543073;SCHEMBL3027713;DTXSID70931337;DIHYDROMORPHINE HYDROCHLORIDE [MI];LS-92185;Q27258007

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Chemical Property of Dihydromorphine hydrochloride

Chemical Property:

• Vapor Pressure: 7.65E-10mmHg at 25°C
• Melting Point: >280 °C
• Boiling Point: 475.4°Cat760mmHg
• Flash Point: 241.3°C
• PSA: 52.93000
• Density: g/cm³
• LogP: 2.16200
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 323.1288213
• Heavy Atom Count: 22
• Complexity: 457

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(CC4)O.Cl
• Isomeric SMILES: CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](CC4)O.Cl

Technology Process of Dihydromorphine hydrochloride

There total 4 articles about Dihydromorphine hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

morphine hydrochloride (52-26-6) → Dihydromorphine hydrochloride (1421-28-9)

Guidance literature:

With hydrogen; In methanol; water; at 25 ℃; for 2h; under 3105.31 Torr;

DOI:10.1055/s-0031-1291151

Reference yield:

MORPHIN (57-27-2) → Dihydromorphine hydrochloride (1421-28-9)

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol;

Reference yield:

6-acetyldihydromorphine hydrobromide → Dihydromorphine hydrochloride (1421-28-9)

Guidance literature:

6-acetyldihydromorphine hydrobromide; With sodium hydroxide;

With hydrogenchloride; In methanol;

DOI:10.3390/molecules25112640

upstream raw materials:

MORPHIN

morphine hydrochloride

(-)-tetrahydrothebaine

Downstream raw materials:

hydromorphone hydrochloride

3-O-acetyldihydromorphine

hydromorphone

Refernces

• 1、 Adler, Martin W.,Bergman, Jack,Chadderdon, Aaron M.,Crowley, Rachel Saylor,Geller, Ellen B.,Hanna, Ramsey D.,Hassan, Sergio A.,Herdman, Christine A.,Inan, Saadet,Irvin, Thomas C.,Jacobson, Arthur E.,Kaska, Sophia,Katz, Jonathan L.,Kopajtic, Theresa A.,Lee, Yong-Sok,Paronis, Carol A.,Prisinzano, Thomas E.,Rice, Kenner C.,Traynor, John R.,Wang, Meining,Withey, Sarah L.. "The intriguing effects of substituents in the N-phenethyl moiety of norhydromorphone: A bifunctional opioid from a set of "tail wags dog" experiments". . . Retrieved 2020.