52-26-6 Usage
Chemical Properties
White or almost white, crystalline powder or colourless, silky needles or cubical masses, efflorescent in a dry atmosphere.
Uses
Opioid receptor agonist; analgesic.
Definition
ChEBI: The hydrochloride salt of morphine.
Contact allergens
Morphine bitartrate caused contact dermatitis in a
worker at a plant producing opium alkaloids. Morphine
hydrochloride and morphine bitartrate showed patchtest-
positive reactions in another patient with contact
dermatitis working in the production of concentrated
poppy straw. We observed a concomitant reaction
between a morphine base and a codeine base in a
patient with drug skin eruption due to codeine.
Safety Profile
Poison by ingestion,
intraperitoneal, intravenous, parenteral, and
subcutaneous routes. An experimental
teratogen. Experimental reproductive
effects. Abuse leads to habituation or
addiction. When heated to decomposition it
emits very toxic fumes of NOx and HCl.
Check Digit Verification of cas no
The CAS Registry Mumber 52-26-6 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 5 and 2 respectively; the second part has 2 digits, 2 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 52-26:
(4*5)+(3*2)+(2*2)+(1*6)=36
36 % 10 = 6
So 52-26-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H19NO3.ClH/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;/h2-5,10-11,13,16,19-20H,6-8H2,1H3;1H/t10-,11+,13-,16-,17-;/m0./s1
52-26-6Relevant articles and documents
Two-step iron(0)-mediated N-demethylation of N -methyl alkaloids
Kok, Gaik B.,Pye, Cory C.,Singer, Robert D.,Scammells, Peter J.
experimental part, p. 4806 - 4811 (2010/10/19)
(Figure Presented) A mild and simple two-step Fe(0)-mediated N-demethylation of a number of tertiary N-methyl alkaloids is described. The tertiary N-methylamine is first oxidized to the corresponding N-oxide, which is isolated as the hydrochloride salt. Subsequent treatment of the N-oxide hydrochloride with iron powder readily provides the N-demethylated amine. Representative substrates include a number of opiate and tropane alkaloids. Key intermediates in the synthesis of semisynthetic 14-hydroxy pharmaceutical opiates such as oxycodone and oxymorphone are also readily N-demethylated using this method.
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