2-Hydroxyethyl palmitate

Base Information

• Chemical Name: 2-Hydroxyethyl palmitate
• CAS No.: 4219-49-2
• Molecular Formula: C18H36O3
• Molecular Weight: 300.482
• Hs Code.: 2915709000
• European Community (EC) Number: 224-160-8,618-403-0
• NSC Number: 406556
• UNII: T80A3T38WE
• DSSTox Substance ID: DTXSID10863345
• Nikkaji Number: J110.953G
• Wikidata: Q27289787
• Mol file: 4219-49-2.mol

Synonyms:PEG-palmitate;polyethyleneglycol palmitate

Chemical Property of 2-Hydroxyethyl palmitate

Chemical Property:

• Vapor Pressure: 1.82E-08mmHg at 25°C
• Melting Point: 51°C
• Refractive Index: 1.455
• Boiling Point: 410.9 °C at 760 mmHg
• PKA: 13.90±0.10(Predicted)
• Flash Point: 156 °C
• PSA: 46.53000
• Density: 0.919 g/cm³
• LogP: 5.00320
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility.: Chloroform (Slightly), Methanol (Slightly)
• Water Solubility.: 1mg/L at 20℃
• XLogP3: 6.8
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 17
• Exact Mass: 300.26644501
• Heavy Atom Count: 21
• Complexity: 217

Purity/Quality:

99.9% ^*data from raw suppliers

EthyleneGlycolMonopalmitate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCCCCCCCCCCCCCC(=O)OCCO
• Uses: Ethylene Glycol Monopalmitate has a strong interaction potential with NFkB, suggesting its use for development of antiinflammatory and anticancer drugs.

Technology Process of 2-Hydroxyethyl palmitate

There total 11 articles about 2-Hydroxyethyl palmitate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethylene glycol (107-21-1) + n-hexadecanoyl chloride (112-67-4) → Monopalmitoylethylene glycol (4219-49-2,9004-94-8)

Guidance literature:

With pyridine; chloroform; N,N-dimethyl-formamide;

DOI:10.1021/ja01118a020

Reference yield:

ethylene glycol (107-21-1) → Monopalmitoylethylene glycol (4219-49-2,9004-94-8)

Guidance literature:

With quinoline; sodium phosphate;

Reference yield:

ethylene glycol (107-21-1) + 1-hexadecylcarboxylic acid (57-10-3) → Monopalmitoylethylene glycol (4219-49-2,9004-94-8)

Guidance literature:

With (1S)-10-camphorsulfonic acid; phenol; at 180 ℃;

upstream raw materials:

2-iodoethyl palmitate

2-bromoethyl hexadecanoate

ethylene glycol

1-hexadecylcarboxylic acid

Downstream raw materials:

phosphoric acid bis-(2-palmitoyloxy-ethyl ester)-phenyl ester

Refernces

• 1、 -. "Combinatorial synthesis of PEG oligomer libraries". Page/Page column 11. . Retrieved 2010/02/15.