(Trimethylsilyl)methanol

Base Information

• Chemical Name: (Trimethylsilyl)methanol
• CAS No.: 3219-63-4
• Molecular Formula: C4H12 O Si
• Molecular Weight: 104.224
• Hs Code.: 2931900090
• European Community (EC) Number: 221-746-5
• NSC Number: 96777
• UNII: E19993083K
• DSSTox Substance ID: DTXSID1062912
• Nikkaji Number: J41.750E
• Wikidata: Q81990352
• Mol file: 3219-63-4.mol

Synonyms:(trimethylsilyl)methanol;1-trimethylsilylmethanol;trimethylsilyl methanol;trimethylsilylmethanol

Chemical Property of (Trimethylsilyl)methanol

Chemical Property:

• Melting Point: <0°C
• Refractive Index: n20/D 1.419(lit.)
• Boiling Point: 120-122 °C754 mm Hg(lit.)
• PKA: 15.92±0.10(Predicted)
• Flash Point: 31.1°C
• PSA: 20.23000
• Density: 0.815g/cm³
• LogP: 1.27440
• Storage Temp.: 2-8°C
• Water Solubility.: Fully miscible in water.
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 104.065741536
• Heavy Atom Count: 6
• Complexity: 37.3

Purity/Quality:

99% ^*data from raw suppliers

Trimethylsilylmethanol ^*data from reagent suppliers

Safty Information:

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C[Si](C)(C)CO
• Uses: 1-Trimethylsilylmethanol is used as nucleophile to resolve the racemate obtained from enantioselective esterification of naproxen (2-(6-methoxy-2-naphthyl) propionic acid) by lipases. It was also used as a nucleophilic hydroxymethylation agent.

Technology Process of (Trimethylsilyl)methanol

There total 14 articles about (Trimethylsilyl)methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

(η5-C5H5)tungsten(dioxo)(CH2SiMe3) (96760-75-7) → (trimethylsilyl)methanol (3219-63-4)

Guidance literature:

With sodium periodate; In tetrahydrofuran-d8; water-d2; at 23 ℃; for 2h; Reagent/catalyst; Temperature; Kinetics; Inert atmosphere;

DOI:10.1021/ja309755g

Reference yield: 100.0%

(η(5)-cyclopentadienyl)oxo(peroxo-O,O')(trimethylsilylmethyl)tungsten (115364-34-6) → (trimethylsilyl)methanol (3219-63-4)

Guidance literature:

With sodium hydroxide; In tetrahydrofuran-d8; water-d2; at 23 ℃; for 3h; Kinetics; Inert atmosphere;

DOI:10.1021/ja309755g

Reference yield: 95.0%

trimethylsilylmethyl acetate (2917-65-9) → (trimethylsilyl)methanol (3219-63-4)

Guidance literature:

With methanol; toluene-4-sulfonic acid; for 3h; Heating;

upstream raw materials:

trimethylsilylmethyl acetate

Tris-(trimethylsilyl-methyl)-boran

Chloromethyltrimethylsilane

methyl (trimethylsilyl)acetate

Downstream raw materials:

me3Si{CH₂O(beo-3.5-ni2)}

Trimethylsilylmethyl trifluoromethanesulfonate

Carbaminsaeure-trimethylsilylmethylester

(2-Isopropyl-5-methyl-cyclohexyloxymethoxymethyl)-trimethyl-silane

Refernces

• 1、 Ekouya et al.. "". . p. C35. Retrieved 1977.
• 2、 -. "Organosilicon Phosphorus-Based Electrolytes". Page/Page column 2-3. . Retrieved 2010/03/02.