Arg-pro-pro-gly-phe

Base Information

• Chemical Name: Arg-pro-pro-gly-phe
• CAS No.: 23815-89-6
• Molecular Formula: C₂₇H₄₀N₈O₆
• Molecular Weight: 572.665
• DSSTox Substance ID: DTXSID40946610
• Nikkaji Number: J413.555E
• ChEMBL ID: CHEMBL1927653
• Mol file: 23815-89-6.mol

Synonyms:Arg-Pro-Pro-Gly-Phe;arginyl-prolyl-prolyl-glycyl-phenylalanine;bradykinin (1-5);thrombostatin

Chemical Property of Arg-pro-pro-gly-phe

Chemical Property:

• Refractive Index: 1.677
• PKA: 3.50±0.10(Predicted)
• PSA: 224.04000
• Density: 1.46 g/cm³
• LogP: 1.03610
• Storage Temp.: −20°C
• XLogP3: -3.4
• Hydrogen Bond Donor Count: 6
• Hydrogen Bond Acceptor Count: 8
• Rotatable Bond Count: 13
• Exact Mass: 572.30708103
• Heavy Atom Count: 41
• Complexity: 981

Purity/Quality:

98%,99%, ^*data from raw suppliers

Bradykinin Fragment 1-5 ≥97% (HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: C1CC(N(C1)C(=O)C2CCCN2C(=O)C(CCCN=C(N)N)N)C(=O)NCC(=O)NC(CC3=CC=CC=C3)C(=O)O
• Isomeric SMILES: C1C[C@H](N(C1)C(=O)[C@@H]2CCCN2C(=O)[C@H](CCCN=C(N)N)N)C(=O)NCC(=O)N[C@@H](CC3=CC=CC=C3)C(=O)O
• Uses: Biologically active fragment of bradykinin

Technology Process of Arg-pro-pro-gly-phe

There total 2 articles about Arg-pro-pro-gly-phe which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

bradykinin (58-82-2) → Bradykinin (1-5) (23815-89-6)

Guidance literature:

With scandium tris(trifluoromethanesulfonate); In water; at 80 ℃; for 40h; Sealed tube;

DOI:10.1039/c6cc10300f

Reference yield:

bradykinin (58-82-2) → L-Ser-L-Pro-L-Phe-L-Arg (16875-08-4) + Bradykinin (1-5) (23815-89-6)

Guidance literature:

With penicillilysin; water; at 30 ℃; for 1h; the specificity and mode of action of reagent; further periods of time (24 h);

DOI:10.1016/0031-9422(93)85082-3

Reference yield:

Bradykinin (1-5) (23815-89-6) + acetylacetone (123-54-6,81235-32-7) → (S)-2-{2-[((S)-1-{(S)-1-[(S)-2-Amino-5-(4,6-dimethyl-pyrimidin-2-ylamino)-pentanoyl]-pyrrolidine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-acetylamino}-3-phenyl-propionic acid

Guidance literature:

With sodium hydrogencarbonate; sodium carbonate; for 72h;

DOI:10.1002/(SICI)1096-9888(199712)32:12<1337::AID-JMS599>3.0.CO;2-X

upstream raw materials:

bradykinin

Refernces

• 1、 Yamaguchi, Megumi,Hanzawa, Satoshi,Hirano, Ken-Ichi,Yamagata, Youhei,Ichishima, Eiji. "SPECIFICITY AND MOLECULAR PROPERTIES OF PENICILLOLYSIN, A METALLOPROTEINASE FROM PENICILLUM CITRINUM". . p. 1317 - 1322. Retrieved 2007/10/02.