Cibenzoline succinate

Base Information

• Chemical Name: Cibenzoline succinate
• CAS No.: 57625-97-5
• Molecular Formula: C₄H₆O₄*C₁₈H₁₈N₂
• Molecular Weight: 380.444
• Mol file: 57625-97-5.mol

Synonyms:CIBENZOLINE SUCCINATE;cifenlinesuccinate

Chemical Property of Cibenzoline succinate

Chemical Property:

• Vapor Pressure: 7.75E-08mmHg at 25°C
• Boiling Point: 449.2 °C at 760 mmHg
• Flash Point: 225.5 °C
• PSA: 123.38000
• Density: g/cm³
• LogP: 5.45320

Purity/Quality:

99% ^*data from raw suppliers

CIBENZOLINE SUCCINATE 95.00% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Cibenzoline succinate

There total 8 articles about Cibenzoline succinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

[14C]-(-)-Cibenzoline (103419-18-7,125836-74-0) + succinic acid (110-15-6) → S-(-)-cibenzoline succinate (57625-97-5,85589-37-3)

Guidance literature:

In methanol; isopropyl alcohol; at 50 - 55 ℃;

Reference yield:

Cibenzoline succinate (57625-97-5,85589-37-3) → R-(+)-cibenzoline succinate (57625-97-5,85589-37-3)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide / 0.5 h / 25 - 30 °C / pH 10.5 - 10.8

2: acetonitrile; water / 0.83 h / 25 - 30 °C

3: sodium hydrogencarbonate / water

4: methanol; isopropyl alcohol / 0.67 h / 25 - 55 °C

With sodium hydrogencarbonate; sodium hydroxide; In methanol; water; isopropyl alcohol; acetonitrile;

Reference yield:

cifenline (53267-01-9,103419-18-7,125836-74-0) → R-(+)-cibenzoline succinate (57625-97-5,85589-37-3)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile; water / 0.83 h / 25 - 30 °C

2: sodium hydrogencarbonate / water

3: methanol; isopropyl alcohol / 0.67 h / 25 - 55 °C

With sodium hydrogencarbonate; In methanol; water; isopropyl alcohol; acetonitrile;

upstream raw materials:

[14C]-(+)-Cibenzoline

succinic acid

Cibenzoline succinate

cifenline

Downstream raw materials:

[14C]-(+)-Cibenzoline

R-(+)-cibenzoline succinate

S-(-)-cibenzoline succinate

[14C]-(-)-Cibenzoline

Refernces

• 1、 -. "Novel Process For The Preparation Of (-)-Cibenzoline Succinate". Paragraph 0233-0241; 0258; 0259. . Retrieved 2020/08/11.