Technology Process of 2,5-Piperazinedione,
1-acetyl-3-[(2,5-dimethoxyphenyl)methyl]-4-(1-methoxyethyl)-
There total 4 articles about 2,5-Piperazinedione,
1-acetyl-3-[(2,5-dimethoxyphenyl)methyl]-4-(1-methoxyethyl)- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
1-acetyl-3-(2,5-dimethoxybenzyl)-piperazine-2,5-dione;
With
trimethylsilyl trifluoromethanesulfonate; N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at -78 ℃;
for 4h;
1,1-dimethoxyethane;
With
trimethylsilyl trifluoromethanesulfonate;
In
dichloromethane;
at -78 ℃;
for 4h;
DOI:10.1016/S0040-4039(03)00897-9
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 98 percent / tBuOK / 2-methyl-propan-2-ol; CH2Cl2 / 4 h
2.1: 98 percent / H2 / Pd-C / methanol / 12 h / 20 °C / 1520 Torr
3.1: TMSOTf; iPr2NEt / CH2Cl2 / 4 h / -78 °C
3.2: 95 percent / TMSOTf / CH2Cl2 / 4 h / -78 °C
With
trimethylsilyl trifluoromethanesulfonate; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; tert-butyl alcohol;
DOI:10.1016/S0040-4039(03)00897-9
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: 98 percent / H2 / Pd-C / methanol / 12 h / 20 °C / 1520 Torr
2.1: TMSOTf; iPr2NEt / CH2Cl2 / 4 h / -78 °C
2.2: 95 percent / TMSOTf / CH2Cl2 / 4 h / -78 °C
With
trimethylsilyl trifluoromethanesulfonate; hydrogen; N-ethyl-N,N-diisopropylamine;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1016/S0040-4039(03)00897-9
