3-Hydroxyquinoline N-oxide

Base Information

• Chemical Name: 3-Hydroxyquinoline N-oxide
• CAS No.: 59953-98-9
• Molecular Formula: C9H7NO2
• Molecular Weight: 161.15700
• Mol file: 59953-98-9.mol

Synonyms:3-Quinolinol 1-oxide;3-hydroxyquinoline N-oxide;3-hydroxyquinoline-1-oxide;

Chemical Property of 3-Hydroxyquinoline N-oxide

Chemical Property:

• PSA: 45.69000
• LogP: 1.97390

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-Hydroxyquinoline N-oxide

There total 2 articles about 3-Hydroxyquinoline N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

3-bromoquinoline N-oxide (22615-00-5) → 3-hydroxyquinoline-1-oxide (59953-98-9)

Guidance literature:

With potassium hydroxide; copper; In water; at 140 - 150 ℃; for 15h;

DOI:10.1007/BF00956546

Reference yield: 72.0%

3-hydroxyquinoline (580-18-7) → 3-hydroxyquinoline-1-oxide (59953-98-9)

Guidance literature:

With phthalic anhydride; urea hydrogen peroxide adduct; In methanol; dichloromethane; for 12h; Reflux;

DOI:10.1002/adsc.202100884

Reference yield: 64.0%

potassium cyanide (151-50-8) + 3-hydroxyquinoline-1-oxide (59953-98-9) → 2-cyano-3-hydroxyquinoline (15462-43-8)

Guidance literature:

With chloro-trimethyl-silane; triethylamine; In N,N-dimethyl-formamide; at 100 - 110 ℃; for 48h;

DOI:10.1021/jm980340j

upstream raw materials:

3-hydroxyquinoline

3-bromoquinoline N-oxide

Downstream raw materials:

2-cyano-3-hydroxyquinoline

Refernces

• 1、 Stief, Laura,Speicher, Andreas. "Setup of 4-Prenylated Quinolines through Suzuki-Miyaura Coupling for the Synthesis of Aurachins A and B". supporting information. p. 158 - 164. Retrieved 2021/10/12.
• 2、 Bergeron, Raymond J.,Wiegand, Jan,Weimar, William R.,Vinson, J. R. Timothy,Bussenius, J?rg,Yao, Guo Wei,McManis, James S.. "Desazadesmethyldesferrithiocin analogues as orally effective iron chelators". . p. 95 - 108. Retrieved 2007/10/03.