Glycinamide

Base Information

• Chemical Name: Glycinamide
• CAS No.: 598-41-4
• Molecular Formula: C2H6N2O
• Molecular Weight: 74.0824
• Hs Code.: 2924199090
• European Community (EC) Number: 209-932-4
• UNII: 4JDT453NWO
• DSSTox Substance ID: DTXSID1060508
• Nikkaji Number: J2.716B
• Wikipedia: Glycinamide
• Wikidata: Q27094555
• Metabolomics Workbench ID: 52325
• ChEMBL ID: CHEMBL86954
• Mol file: 598-41-4.mol

Synonyms:glycinamide;glycine amide;glycine amide hydrobromide;glycine amide hydrochloride

Chemical Property of Glycinamide

Chemical Property:

• Melting Point: 65-67 °C
• Boiling Point: 281.3 °C at 760 mmHg
• PKA: pK1: 7.95(+1) (25°C)
• Flash Point: 123.9 °C
• PSA: 69.11000
• Density: 1.122 g/cm³
• LogP: -0.16900
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• XLogP3: -1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 74.048012819
• Heavy Atom Count: 5
• Complexity: 42.9

Purity/Quality:

99% ^*data from raw suppliers

Glycinamide 99 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C(C(=O)N)N

Technology Process of Glycinamide

There total 61 articles about Glycinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

→ H-Gly-NH2 (598-41-4)

Guidance literature:

With p-cresol; hydrogen fluoride; at 0 ℃; for 1h;

DOI:10.1016/S0040-4039(01)81767-6

Reference yield: 73.0%

→ H-Gly-NH2 (598-41-4) + glyoxylglycylhistamine

Guidance literature:

With Oxone; nickel(II) perchlorate; at 25 ℃; pH=5.4 - 7.0;

DOI:10.1039/b409929j

Reference yield: 65.0%

2-aminoacetonitrile (540-61-4) → glycine (56-40-6,18875-39-3,25718-94-9) + H-Gly-NH2 (598-41-4)

Guidance literature:

With water; In aq. buffer; at 10 - 30 ℃; for 300h; pH=11; Kinetics; Mechanism; Inert atmosphere; Electrolysis;

DOI:10.14233/ajchem.2016.19405

upstream raw materials:

2-azido-acetamide

iodo-acetic acid-(hydroxymethyl-amide)

glycine

GlyOEt*HCl

Downstream raw materials:

N-(carbobenzyloxy)glycinamide

2,3-Dimethyl-5-hydroxypyrazine

2-(((benzylthio)carbonothioyl)amino)acetic acid

2-formylaminoacetamide

Refernces

• 1、 Ganguly, Bishwajit,Kesharwani, Manoj K.,Basari?, Nikola,Suresh, Eringathodi,Biswas, Abul Kalam,Mlinari?-Majerski, Kata. "Conformational preference of glycinamide in solution: An answer derived from combined experimental and computational studies". . p. 52 - 58. Retrieved 2013.
• 2、 -. "Corresponding amine nitrile and method of manufacturing thereof". Paragraph 0138; 0139; 0140; 0145; 0146. . Retrieved 2018/05/07.
• 3、 -. "HEMIAMINAL-TAG FOR PROTEIN LABELING AND PURIFICATION". Page/Page column 22. . Retrieved 2018/06/30.