N,N-Dipropylformamide

Base Information

• Chemical Name: N,N-Dipropylformamide
• CAS No.: 6282-00-4
• Molecular Formula: C7H15NO
• Molecular Weight: 129.202
• Hs Code.: 2924199090
• NSC Number: 5944
• UNII: 4W148KAK90
• DSSTox Substance ID: DTXSID70211929
• Nikkaji Number: J49.549B
• Wikidata: Q27160110
• Mol file: 6282-00-4.mol

Synonyms:N,N-Dipropylformamide;6282-00-4;N,N-Di-n-propylformamide;Formamide, N,N-dipropyl-;NN-Dipropylformamide;FORMAMIDE, N,N-DI-n-PROPYL-;NSC 5944;N-N-Di-n-propylformamide;BRN 0635928;AI3-18808;4W148KAK90;NSC-5944;Dipropylformamide;NSC5944;Dipropylformamide #;formamide, dipropyl-;Formamide,N-dipropyl-;n,n-dipropyl-formamide;Formamide,N-di-n-propyl-;SCHEMBL2916;UNII-4W148KAK90;WLN: VHN3&3;CHEBI:88185;DTXSID70211929;Formamide, N,N-dipropyl- (8CI);MFCD00043518;AKOS006230620;CS-W011117;DS-11712;LS-69474;FT-0629577;D70355;A868356;Q27160110

Chemical Property of N,N-Dipropylformamide

Chemical Property:

• Appearance/Colour: yellowish gray liquid
• Vapor Pressure: 0.108mmHg at 25°C
• Refractive Index: 1.4395
• Boiling Point: 221.3 °C at 760 mmHg
• Flash Point: 83.7 °C
• PSA: 20.31000
• Density: 0.869 g/cm³
• LogP: 1.90070
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 4
• Exact Mass: 129.115364102
• Heavy Atom Count: 9
• Complexity: 67.3

Purity/Quality:

98%,99%, ^*data from raw suppliers

N,N-Dipropylformamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): R36/38:Irritating to eyes and skin.
• Hazard Codes: R36/38:Irritating to eyes and skin.
• Statements: 36/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCCN(CCC)C=O

Technology Process of N,N-Dipropylformamide

There total 17 articles about N,N-Dipropylformamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

carbon dioxide (124-38-9,18923-20-1) + di-n-propylamine (142-84-7) → N,N-di-n-propylformamide (6282-00-4)

Guidance literature:

With tris(2-diphenylphosphinoethyl)phosphine; hydrogen; potassium carbonate; cobalt(II) perchlorate hexahydrate; In ethanol; at 140 ℃; for 24h; under 45004.5 Torr; Autoclave; Green chemistry;

DOI:10.1039/c8nj03047b

Reference yield: 90.0%

N,N-di-n-propyl-1-imidazolecarboxamide (66772-82-5) → N,N-di-n-propylformamide (6282-00-4)

Guidance literature:

With sodium tetrahydroborate; In tetrahydrofuran; water; at 20 ℃;

DOI:10.1016/j.tetlet.2017.04.072

Reference yield: 88.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + di-n-propylamine (142-84-7) → N,N-di-n-propylformamide (6282-00-4)

Guidance literature:

With sodium hydroxide; In water; at 25 ℃; for 6h;

DOI:10.1039/c5gc01992c

upstream raw materials:

dipropyl-oxalamic acid

formic acid

di-n-propylamine

carbon monoxide

Downstream raw materials:

4,5-dihydro-1,3-diphenyl-5-oxo-1H-pyrazole-4-carboxaldehyde

S-Phenyl N,N-dipropylthiocarbamate

N,N-dipropylbenzamide

N-methyldipropylamine

Refernces

• 1、 Li, Ruipeng,Zhao, Yanfei,Li, Zhiyong,Wu, Yunyan,Wang, Jianji,Liu, Zhimin. "Choline-based ionic liquids for CO2 capture and conversion". . p. 256 - 261. Retrieved 2018/11/23.
• 2、 Lei, Lin-Sheng,Xue, Cao-Gen,Xu, Xue-Tao,Jin, Da-Ping,Wang, Shao-Hua,Bao, Wen,Liang, Huan,Zhang, Kun,Asiri, Abdullah M.. "The synthesis of cyanoformamides via a CsF-promoted decyanation/oxidation cascade of 2-dialkylamino-malononitriles". supporting information. p. 3723 - 3726. Retrieved 2019/04/17.