1-methyl-4-phenyl-piperidine

Base Information

• Chemical Name: 1-methyl-4-phenyl-piperidine
• CAS No.: 774-52-7
• Molecular Formula: C12H17N
• Molecular Weight: 175.274
• Mol file: 774-52-7.mol

Synonyms:Piperidine,1-methyl-4-phenyl;4-Phenyl-1-methyl-piperidine;1-Methyl-4-phenyl-piperidine;1-Methyl-4-phenyl-piperidin;1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine;N-methyl-4-phenylpiperidine;

Chemical Property of 1-methyl-4-phenyl-piperidine

Chemical Property:

• Vapor Pressure: 0.0177mmHg at 25°C
• Melting Point: 9 °C
• Boiling Point: 254°C at 760 mmHg
• PKA: 8.97±0.10(Predicted)
• Flash Point: 98.2°C
• PSA: 3.24000
• Density: 0.964g/cm³
• LogP: 2.43370
• Storage Temp.: Sealed in dry,Room Temperature

Purity/Quality:

NLT 98% ^*data from raw suppliers

1-Methyl-4-phenylpiperidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-methyl-4-phenyl-piperidine

There total 21 articles about 1-methyl-4-phenyl-piperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

4-(4-bromophenyl)-1-methyl-1,2,3,6-tetrahydropyridine (180912-08-7) → 1-methyl-4-phenylpiperidine (774-52-7)

Guidance literature:

With hydrogen; acetic acid; palladium 10% on activated carbon; for 19h;

Reference yield: 76.0%

methanol (67-56-1) + 4-phenylpiperidine (771-99-3) → 1-methyl-4-phenylpiperidine (774-52-7)

Guidance literature:

With trimethylamine-N-oxide; tricarbonyl(η⁴-1,3-bis(trimethylsilyl)-4,5,6,7-tetrahydro-2H-inden-2-one)iron; potassium carbonate; at 110 ℃; for 24h;

DOI:10.1021/acscatal.8b02158

Reference yield: 74.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + 4-phenylpiperidine (771-99-3) → 1-methyl-4-phenylpiperidine (774-52-7)

Guidance literature:

With formic acid;

DOI:10.1021/jm00126a013

upstream raw materials:

formaldehyd

4-phenylpiperidine hydrochloride

4-phenylpiperidine

methyl iodide

Downstream raw materials:

1,1'-dimethyl-4,4'-diphenyl-1,1'-butanediyl-bis-piperidinium; dibromide

1,1'-dimethyl-4,4'-diphenyl-1,1'-pentanediyl-bis-piperidinium; dibromide

1-ethyl-1-methyl-4-phenyl-piperidinium; iodide

1-methyl-4-(4-nitrophenyl)-piperidine

Refernces

• 1、 -. "Pyrazolo [3,4 - the b] pyridine and [...] composition preparation method and use of (by machine translation)". Paragraph 0438; 0439; 0440; 0441. . Retrieved 2017/07/22.
• 2、 Pretorius, Anél,Ogunrombi, Modupe O.,Fourie, Hendrik,Terre'Blanche, Gisella,Castagnoli Jr., Neal,Bergh, Jacobus J.,Petzer, Jacobus P.. "Interactions of 1-methyl-3-phenylpyrrolidine and 3-methyl-1-phenyl-3-azabicyclo[3.1.0]hexane with monoamine oxidase B". experimental part. p. 4111 - 4118. Retrieved 2010/08/03.