Cephaeline methyl ether hydrochloride

Base Information

• Chemical Name: Cephaeline methyl ether hydrochloride
• CAS No.: 316-42-7
• Molecular Formula: C₂₉H₄₀N₂O₄*2ClH
• Molecular Weight: 553.569
• European Community (EC) Number: 206-259-8
• NSC Number: 752340,33669
• DSSTox Substance ID: DTXSID80424947
• NCI Thesaurus Code: C29018
• ChEMBL ID: CHEMBL513000
• Mol file: 316-42-7.mol

Synonyms:Dihydrochloride, Emetine;Emetine;Emetine Dihydrochloride;Emetine Hydrochloride;Hydrochloride, Emetine;Ipecine;Methylcephaeline

Chemical Property of Cephaeline methyl ether hydrochloride

Chemical Property:

• Appearance/Colour: white powder or crystals
• Vapor Pressure: 8.91E-17mmHg at 25°C
• Melting Point: 240-250 °C (dec., dry matter)(lit.)
• Boiling Point: 600.3 °C at 760 mmHg
• Flash Point: 316.9 °C
• PSA: 52.19000
• Density: g/cm³
• LogP: 6.81410
• Storage Temp.: 2-8°C
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 7
• Exact Mass: 516.2754855
• Heavy Atom Count: 36
• Complexity: 679

Purity/Quality:

96% ^*data from raw suppliers

Emetine, Dihydrochloride ≥98%(HPLC) ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T+
• Hazard Codes: T+
• Statements: 28-36/37/38
• Safety Statements: 26-28-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCC1CN2CCC3=CC(=C(C=C3C2CC1CC4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl
• Isomeric SMILES: CC[C@H]1CN2CCC3=CC(=C(C=C3[C@@H]2C[C@@H]1C[C@@H]4C5=CC(=C(C=C5CCN4)OC)OC)OC)OC.Cl
• Recent ClinicalTrials: Evaluating Emetine for Viral Outbreaks (EVOLVE)
• Description: As the principal alkaloid of ipecac, Emetine dihydrochloride is derived from Uragoga ipecacuanha ground roots, which is used in the treatment of amebiasis. It can? also be used as an emetic to induce vomiting. Emetine dihydrochloride functions by inhibiting ribosome movement along mRNA, which results in irreversibly blocking protein synthesis in eukaryotic cells? instead of prokaryotic cells. Besides, it has been proved that it can induce hypotension through blocking adrenoreceptors.
• Uses: Anti-amebic. Emetine, an alkaloid from ipecac, C29H40O4N2, is a white powder with a very bitter taste. The substance is soluble in alcohol and ether, slightly soluble in water. Emetine darkens upon exposure to light. The compound is derived by extraction from the root of Cephalis ipecacuanha (ipecac). It is also made synthetically. Medically, ipecac is useful as an emetic (induces vomiting) for emergency use in the treatment of drug overdosage and in certain cases of poisoning. Ipecac should not be administered to persons in an unconscious state. It should be noted that emesis is not the proper treatment in all cases of potential poisoning. It should not be induced when such substances as petroleum distillates, strong alkali, acids, or strychnine are ingested. Emetine dihydrochloride has been used:as a protein synthesis inhibitor to study its effects on human papillomavirus type 8 E2 protein half-lifeto study its effects on the stress granules assemblyas a chain-elongation inhibitor in puromycin assay for protein synthesis