Opipramol

Base Information

• Chemical Name: Opipramol
• CAS No.: 315-72-0
• Molecular Formula: C23H29 N3 O
• Molecular Weight: 363.503
• Hs Code.: 2933990090
• European Community (EC) Number: 206-254-0
• NSC Number: 169867
• UNII: D23ZXO613C
• DSSTox Substance ID: DTXSID3023394
• Nikkaji Number: J8.634G
• Wikipedia: Opipramol
• Wikidata: Q416562
• NCI Thesaurus Code: C90612
• Pharos Ligand ID: KGST4LNQV3N4
• Metabolomics Workbench ID: 153818
• ChEMBL ID: CHEMBL370753
• Mol file: 315-72-0.mol

Synonyms:Hydrochloride, Opipramol;Insidon;Opipramol;Opipramol Hydrochloride

Chemical Property of Opipramol

Chemical Property:

• Melting Point: 100-1010C
• Refractive Index: 1.6500 (estimate)
• Boiling Point: 555.1 °C at 760 mmHg
• PKA: pKa 8(H2O,t =25,I=0.01(NaCl)) (Uncertain)
• Flash Point: 290.5 °C
• PSA: 29.95000
• Density: 1.129 g/cm³
• LogP: 3.24930
• Storage Temp.: -20°C Freezer
• XLogP3: 3.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 363.231062557
• Heavy Atom Count: 27
• Complexity: 448

Purity/Quality:

99.9% ^*data from raw suppliers

Opipramol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn,N
• Hazard Codes: Xn,N
• Statements: 22-50/53
• Safety Statements: 60-61

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CN(CCN1CCCN2C3=CC=CC=C3C=CC4=CC=CC=C42)CCO
• Recent ClinicalTrials: Selected Disorders and Sleep Bruxism
• Uses: Antidepressant; antipsychotic
• Therapeutic Function: Antidepressant, Antipsychotic

Technology Process of Opipramol

There total 4 articles about Opipramol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.3%

2,4-di-tert-Butylphenol (96-76-4) → tris(2,4-di-tert-butylphenyl)phosphite (31570-04-4)

Guidance literature:

2,4-di-tert-Butylphenol; With pyridine; In methanol; toluene; at 5 - 40 ℃;

With phosphorus trichloride; In methanol; toluene; at 95 ℃; for 0.5h; Reagent/catalyst; Temperature;

Reference yield:

para-tert-butylphenol (98-54-4) + 2,4-di-tert-Butylphenol (96-76-4) → tris(2,4-di-tert-butylphenyl)phosphite (31570-04-4) + tris(4-(tert-butyl)phenyl) phosphite (4235-89-6) + bis(4-tert-butylphenyl)-2,4-di-tert-butylphenyl phosphite (1000027-03-1) + bis(2,4-di-tert-butylphenyl)-4-tert-butylphenyl phosphite (161519-57-9)

Guidance literature:

With N,N-dimethylaminododecane; phosphorus trichloride; at 90 - 200 ℃; under 37.5038 - 750.075 Torr; Product distribution / selectivity; Inert atmosphere;

Reference yield:

→ tris(2,4-di-tert-butylphenyl)phosphite (31570-04-4)

Guidance literature:

upstream raw materials:

para-tert-butylphenol

2,4-di-tert-Butylphenol

Downstream raw materials:

8-(3-<4-(2-hydroxyethyl)piperazinyl>propyl)-8H-dibenz<1>oxa<2,5>diazolo<3,4-d>azepine 1-oxide

Refernces

• 1、 -. "Novel process route of synthesizing antioxidant 168". Paragraph 0038-0040; 0044-0046; 0050-0052; 0056-0058; 0062. . Retrieved 2018/09/26.
• 2、 -. "COUMESTAN-LIKE ANTIOXIDANTS AND UV ABSORBANTS". . . Retrieved 2011/01/05.