6-Methoxyquinoxaline

Base Information

• Chemical Name: 6-Methoxyquinoxaline
• CAS No.: 6639-82-3
• Molecular Formula: C9H8N2O
• Molecular Weight: 160.175
• Hs Code.: 2933990090
• European Community (EC) Number: 802-039-6
• NSC Number: 48944
• DSSTox Substance ID: DTXSID50287102
• Wikidata: Q72486017
• Mol file: 6639-82-3.mol

Synonyms:6-methoxyquinoxaline;6639-82-3;Quinoxaline, 6-methoxy-;MFCD00666601;NSC48944;SCHEMBL622115;DTXSID50287102;NSC-48944;AKOS005256194;CS-W000649;AS-41589;FT-0621203

Chemical Property of 6-Methoxyquinoxaline

Chemical Property:

• Vapor Pressure: 0.00545mmHg at 25°C
• Melting Point: 58.9°C
• Refractive Index: 1.618
• Boiling Point: 283.3 °C at 760 mmHg
• PKA: 1.22±0.30(Predicted)
• Flash Point: 97.9 °C
• PSA: 35.01000
• Density: 1.195 g/cm³
• LogP: 1.63840
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 160.063662883
• Heavy Atom Count: 12
• Complexity: 152

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Methoxyquinoxaline ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC2=NC=CN=C2C=C1

Technology Process of 6-Methoxyquinoxaline

There total 2 articles about 6-Methoxyquinoxaline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 4.0%

(3-Methoxy-phenyl)-[2-(phenyl-hydrazono)-eth-(E)-ylidene]-amine → 6-methoxyquinoxaline (6639-82-3) + 5-methoxyquinoxaline (19506-17-3)

Guidance literature:

at 600 ℃; for 0.583333h; under 0.005 Torr;

Reference yield:

ethylene glycol (107-21-1) + 4-methoxy-1,2-phenylenediamine (102-51-2) → 6-methoxyquinoxaline (6639-82-3) + 5-methoxy-1H-benzimidazole (4887-80-3) + 4,4'-dimethyloxyazobenzene-2,2'-diamine (92050-12-9)

Guidance literature:

With air; silver-loaded TiO₂/montmorillonite K₁₀; In acetonitrile; for 8h; Solar light irradiation;

DOI:10.1246/bcsj.20090319

Reference yield: 92.0%

6-methoxyquinoxaline (6639-82-3) → 6-methoxy-1,2,3,4-tetrahydroquinoxaline (13311-79-0)

Guidance literature:

With tetrabutylammomium bromide; 4,4,5,5-tetramethyl-[1,3,2]-dioxaboralane; In tetrahydrofuran; at 80 ℃; for 93h; Inert atmosphere; Schlenk technique; Glovebox;

DOI:10.1021/acs.joc.1c02537

upstream raw materials:

ethylene glycol

4-methoxy-1,2-phenylenediamine

Downstream raw materials:

6-hydroxyquinoxaline

6-methoxy-1,2,3,4-tetrahydroquinoxaline

5-Amino-6-methoxychinoxalin

1,4-dioxy-quinoxalin-6-ol

Refernces

• 1、 McNab, Hamish. "The Thermolysis of Polyazapentadienes. Part 2. Formation of Quinoxalines from 5-Aryl-1-phenyl-1,2,5-triazapentadienes". . p. 1941 - 1946. Retrieved 2007/10/02.