Propanamide, N-(6-aminohexyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

Base Information

• Chemical Name: Propanamide, N-(6-aminohexyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-
• CAS No.: 678188-84-6
• Molecular Formula: C22H37N3O
• Molecular Weight: 359.555
• Mol file: 678188-84-6.mol

Synonyms:

Chemical Property of Propanamide, N-(6-aminohexyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Propanamide, N-(6-aminohexyl)-N-[1-(2-phenylethyl)-4-piperidinyl]-

There total 4 articles about Propanamide, N-(6-aminohexyl)-N-[1-(2-phenylethyl)-4-piperidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

tert-butyl {6-[(1-phenethylpiperidin-4-yl)propionylamino]hexyl}carbamate (678188-79-9) → N-(6-amino-hexyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide (678188-84-6)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.5h;

DOI:10.1016/j.bmcl.2003.10.048

Reference yield:

1,6-Hexanediamine (124-09-4) → N-(6-amino-hexyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide (678188-84-6)

Guidance literature:

Multi-step reaction with 4 steps

1: CHCl₃ / 20 °C

2: 64 percent / NaBH₃CN; AcOH; 4 Angstroem sieves / methanol / 20 °C / pH 7 - 8

3: 73 percent / DMAP; pyridine / CH₂Cl₂ / 20 °C

4: CF₃CO₂H / CH₂Cl₂ / 0.5 h

With pyridine; dmap; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane; chloroform;

DOI:10.1016/j.bmcl.2003.10.048

Reference yield:

tert-butyl N-(6-aminohexyl)carbamate (51857-17-1) → N-(6-amino-hexyl)-N-(1-phenethyl-piperidin-4-yl)-propionamide (678188-84-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 64 percent / NaBH₃CN; AcOH; 4 Angstroem sieves / methanol / 20 °C / pH 7 - 8

2: 73 percent / DMAP; pyridine / CH₂Cl₂ / 20 °C

3: CF₃CO₂H / CH₂Cl₂ / 0.5 h

With pyridine; dmap; 4 A molecular sieve; sodium cyanoborohydride; acetic acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1016/j.bmcl.2003.10.048

upstream raw materials:

tert-butyl {6-[(1-phenethylpiperidin-4-yl)propionylamino]hexyl}carbamate

1,6-Hexanediamine

tert-butyl N-(6-aminohexyl)carbamate

tert-butyl [6-(1-phenethylpiperidin-4-ylamino)hexyl]carbamate

Downstream raw materials:

C₃₃H₅₅N₅O₅

Refernces