6-Amino-2-hydroxypyridine

Base Information

• Chemical Name: 6-Amino-2-hydroxypyridine
• CAS No.: 5154-00-7
• Molecular Formula: C5H6N2O
• Molecular Weight: 110.115
• Hs Code.: 29333999
• Mol file: 5154-00-7.mol

Synonyms:2-Pyridinol,6-amino- (8CI);(6-Hydroxypyridin-2-yl)amine;

Chemical Property of 6-Amino-2-hydroxypyridine

Chemical Property:

• Melting Point: 211-212 °C
• Boiling Point: 358.7 °C at 760 mmHg
• PKA: 10.32±0.10(Predicted)
• Flash Point: 170.7 °C
• PSA: 59.14000
• Density: 1.208 g/cm³
• LogP: 0.95060
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature

Purity/Quality:

98%,99%, ^*data from raw suppliers

6-Amino-2(1H)-pyridinone ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xn
• Hazard Codes: T,Xn
• Statements: 36/37/38-20/21/22-36-22-41-37/38
• Safety Statements: 26-36/37/39-36-60

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 6-Amino-2(1H)-pyridinone can be used as a reactant to synthesize pyrido[1,2-a]pyrimidin-4-one derivatives as selective aldose reductase inhibitors exhibiting antioxidant activity. It can also be used to synthesize carbamoyloxy derivatives of 2-substituted imidazo[1,2-a]pyridinium salts with acetylcholinesterase inhibitory activity.

Technology Process of 6-Amino-2-hydroxypyridine

There total 6 articles about 6-Amino-2-hydroxypyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

2-Pyridone (142-08-5,1199357-22-6) → 6-aminopyridine-2(1H)-one (5154-00-7)

Guidance literature:

With sodium amide; In mineral oil; at 20 - 210 ℃;

DOI:10.1016/j.tetlet.2015.12.013

Reference yield: 32.0%

2.6-diaminopyridine (141-86-6) → 6-amino-pyridin-2-ol (5154-00-7,59315-47-8)

Guidance literature:

With hydrogenchloride; water; for 3h; Reflux;

DOI:10.1039/c3dt50642h

Reference yield:

6-hydroxy-pyridine-2-carboxylic acid amide (89640-67-5) → 6-amino-pyridin-2-ol (5154-00-7,59315-47-8)

Guidance literature:

With sodium hypobromide;

upstream raw materials:

2.6-diaminopyridine

6-hydroxy-pyridine-2-carboxylic acid amide

6-amino-pyridin-2-ol

sulfuric acid

Downstream raw materials:

6-amino-2-hydroxy-pyridine-3-carboxylic acid

pyridine

C₁₀H₁₄N₂O₂

2-Amino-5-hydroxy-thiazolo<4.5-b>pyridin

Refernces

• 1、 Mastalir, Matthias,Pittenauer, Ernst,Allmaier, Günter,Kirchner, Karl. "2,6-Diamination of substituted pyridines via heterogeneous Chichibabin reaction". supporting information. p. 333 - 336. Retrieved 2016/01/12.