CID 657219

Base Information

• Chemical Name: CID 657219
• CAS No.: 10347-81-6
• Molecular Formula: C20H23N^.HCl
• Molecular Weight: 313.87
• Hs Code.: 2921490002
• Mol file: 10347-81-6.mol

Synonyms:SCHEMBL14973468;AKOS015896333

Chemical Property of CID 657219

Chemical Property:

• Appearance/Colour: Crystalline solid
• Vapor Pressure: 9.8E-08mmHg at 25°C
• Melting Point: 230-232 °C
• Boiling Point: 399.6 °C at 760 mmHg
• Flash Point: 187.7 °C
• PSA: 12.03000
• LogP: 5.40430
• Storage Temp.: Store at RT
• Solubility.: H2O: 50 mg/mL
• Water Solubility.: Soluble to 50mg/ml in water. Soluble in ethanol at 10mM
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 4
• Exact Mass: 313.1597275
• Heavy Atom Count: 22
• Complexity: 339

Purity/Quality:

98%,99%, ^*data from raw suppliers

Maprotiline hydrochloride ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xn
• Hazard Codes: Xn,T,F
• Statements: 22-39/23/24/25-23/24/25-11
• Safety Statements: 7-16-36/37-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: [H+].CNCCCC12CCC(C3=CC=CC=C31)C4=CC=CC=C24.[Cl-]
• Description: Maprotiline is a tricyclic antidepressant. It binds to the norepinephrine transporter (NET; Kd = 11 nM) and is selective for NET over the serotonin (5-HT) and dopamine transporters (Kds = 5,800 and 1,000 nM, respectively). Maprotiline also binds to the 5-HT receptor subtype 5-HT2A (KI = 51 nM), as well as histamine H1, muscarinic acetylcholine, α1-adrenergic, and dopamine D2 receptors (Kds = 2, 570, 90, and 350 nM, respectively). In vivo, maprotiline inhibits norepinephrine reuptake in rat brain and peripheral tissues. It reduces isolation-induced aggressive behavior and inhibits electrical foot-shock stimulation-induced belligerence in mice when administered at doses ranging from 3 to 10 mg/kg. Maprotiline (20 μM) prevents acid sphingomyelinase activation and subsequent ceramide release induced by infection with replication-deficient vesicular stomatitis virus pseudoviral particles (pp-VSV) presenting the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike protein in Vero cells, an effect that can be overcome with exogenous application of C16 ceramide . Formulations containing maprotiline have been used in the treatment of depression and anxiety. This product is also available as an analytical reference material (Item Nos. 32702 | 33077).
• Uses: Antidepressant estrogen, with progesterone as oral contraceptive Maprotiline Hydrochloride has also been shown to block apoptosis of spiny neurons and inhibit SLC6A2.
• Therapeutic Function: Antidepressant