Oxamic acid

Base Information

• Chemical Name: Oxamic acid
• CAS No.: 471-47-6
• Molecular Formula: C2H3NO3
• Molecular Weight: 89.0507
• Hs Code.: 29241990
• European Community (EC) Number: 207-443-0
• NSC Number: 47001
• UNII: QU60N5OPLG
• DSSTox Substance ID: DTXSID6060052
• Nikkaji Number: J5.942K
• Wikipedia: Oxamic_acid,Oxamate
• Wikidata: Q27094801
• Metabolomics Workbench ID: 51140
• ChEMBL ID: CHEMBL15976
• Mol file: 471-47-6.mol

Synonyms:Acid, Aminooxoacetic;Acid, Oxalamic;Acid, Oxamic;Acid, Oxamidic;Aminooxoacetic Acid;Oxalamic Acid;Oxamic Acid;Oxamidic Acid

Chemical Property of Oxamic acid

Chemical Property:

• Appearance/Colour: white crystalline powder
• Vapor Pressure: 0.000177mmHg at 25°C
• Melting Point: 207-210 °C (dec.)(lit.)
• Refractive Index: 1.4264 (estimate)
• Boiling Point: 306.3 °C at 760 mmHg
• PKA: 1.60±0.20(Predicted)
• Flash Point: 139 °C
• PSA: 80.39000
• Density: 1.563 g/cm³
• LogP: -0.74340
• Storage Temp.: 2-8°C(protect from light)
• Solubility.: DMSO (Slightly), Methanol (Slightly), Water (Slightly)
• Water Solubility.: Soluble in water 108 mg/mL.
• XLogP3: -0.9
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 89.011292958
• Heavy Atom Count: 6
• Complexity: 86.8

Purity/Quality:

98%,99%, ^*data from raw suppliers

Oxamic acid ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Pesticides -> Insect Repellents,Nitrogen Compounds -> Amino Carboxylic Acids
• Canonical SMILES: C(=O)(C(=O)O)N
• Uses: Oxamic acid is an ozone oxidation product and is used in the synthesis of hydroxybenzimidazoles preparation as potential anti tumor agents targeting human lactate dehydrogenase A.This compound is suitable for lactate dehydrogenase (LDH) related research.

Technology Process of Oxamic acid

There total 38 articles about Oxamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

amoxicillin (26787-78-0,81030-75-3) → Thiazole-4-carboxylic acid (3973-08-8) + 5,5-Dimethyl-4,5-dihydro-thiazole-4-carboxylic acid (740742-98-7) + formic acid (64-18-6) + glycolic Acid (79-14-1) + 1,5-pentanedioic acid (110-94-1) + Adipic acid (124-04-9) + tartronic acid (80-69-3) + glyceric acid (473-81-4,118916-26-0) + oxamic acid (471-47-6) + succinic acid (110-15-6) + C5H8O6S (1378848-02-2) + pisolithin A (15573-67-8) + C9H10N2O4 + C9H12N2O5S + C8H10N2O6S + C9H14N2O7S + C9H12N2O6S + C8H10N2O4S + C10H12N2O7S + C15H21N3O4S (1356020-01-3,57414-05-8) + C15H18N2O4S + C14H21N3O3S + C8H12N2O4S + C8H10N2O5S + C6H10O7S + C6H7NO4S + C6H11NO3S + C6H9NO3S + oxalic acid (144-62-7,97993-78-7) + acetic acid (64-19-7,77671-22-8) + propionic acid (802294-64-0,79-09-4) + 2-oxo-propionic acid (127-17-3) + tartaric acid (87-69-4,138508-61-9) + 6-aminopenicillanic acid (551-16-6) + benzoic acid (65-85-0,8013-63-6) + Glyoxilic acid (298-12-4) + 2-hydroxy-3-(4-hydroxyphenyl)pyrazine + 2-butenedioic acid (6915-18-0,26099-09-2) + butyric acid (107-92-6) + (4S)-2t-{(R)-[(R)-2-amino-2-(4-hydroxy-phenyl)-acetylamino]-carboxy-methyl}-5,5-dimethyl-thiazolidine-4r-carboxylic acid (57457-65-5) + 4-hydroxy-benzoic acid (99-96-7)

Guidance literature:

With Ru/CNT; sodium hydroxide; for 8h; Reagent/catalyst; Electrolysis;

DOI:10.1016/j.cattod.2019.06.039

Reference yield:

parabanic acid (120-89-8) → Oxalamide (471-46-5) + oxamic acid (471-47-6) + urea (57-13-6)

Guidance literature:

With water; Product distribution; Irradiation; further N-, / O-heterocycles, H₂O-addition/hydrolysis, oxydation, CO-elimination;

Reference yield:

oxalic acid amide ureide (617-49-2) + ammonia (7664-41-7) → oxamic acid (471-47-6) + oxalic acid (144-62-7,97993-78-7) + urea (57-13-6)

Guidance literature:

upstream raw materials:

LACTIC ACID

N-hydroxyoxamide

malic acid

Oxalamide

Downstream raw materials:

piperazine-2,3,5,6-tetraone

cyanic acid

Glyoxilic acid

potassium oxamate

Refernces

• 1、 Guzmán-Mar, Jorge L.,Hernández-Ramírez, Aracely,Hinojosa-Reyes, Laura,Mendiola-Alvarez, Sandra Y.,Palomino-Cabello, Carlos,Turnes-Palomino, Gemma. "Coupled heterogeneous photocatalysis using a P-TiO2-αFe2O3 catalyst and K2S2O8 for the efficient degradation of a sulfonamide mixture". . . Retrieved 2020/03/18.
• 2、 Bedolla-Guzman, Alejandro,Sirés, Ignasi,Thiam, Abdoulaye,Peralta-Hernández, Juan Manuel,Gutiérrez-Granados, Silvia,Brillas, Enric. "Application of anodic oxidation, electro-Fenton and UVA photoelectro-Fenton to decolorize and mineralize acidic solutions of Reactive Yellow 160 azo dye". . p. 307 - 316. Retrieved 2016/05/11.