Tetramic acid

Base Information

• Chemical Name: Tetramic acid
• CAS No.: 503-83-3
• Molecular Formula: C4H5NO2
• Molecular Weight: 99.0892
• Hs Code.: 2933990090
• Mol file: 503-83-3.mol

Synonyms:3-Pyrrolin-2-one,4-hydroxy- (7CI,8CI);

Chemical Property of Tetramic acid

Chemical Property:

• Vapor Pressure: 0.00108mmHg at 25°C
• Melting Point: 120 °C
• Refractive Index: 1.579
• Boiling Point: 267.706 °C at 760 mmHg
• PKA: 4.50±1.00(Predicted)
• Flash Point: 115.705 °C
• PSA: 49.33000
• Density: 1.425 g/cm³
• LogP: -0.11310

Purity/Quality:

99%, ^*data from raw suppliers

4-Hydroxy-1H-pyrrol-2(5H)-one 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Tetramic acid

There total 2 articles about Tetramic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

ethyl 2-(N-(4-methoxybenzyl)dodecanamido)acetate → 4-hydroxy-1H-pyrrol-2(5H)-one (503-83-3) + 3-decyl-1-(4-methoxybenzyl)pyrrolidine-2,4-dione

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 1.5h; Inert atmosphere; Reflux;

DOI:10.3762/bjoc.14.224

Reference yield:

methyl 2,4-dioxo-3-pyrrolidinecarboxylate (51925-57-6) → 4-hydroxy-1H-pyrrol-2(5H)-one (503-83-3) + pyrrolidine-2,4-dione (37772-89-7)

Guidance literature:

With water; In 1,4-dioxane; for 0.5h; Reflux;

upstream raw materials:

methyl 2,4-dioxo-3-pyrrolidinecarboxylate

Refernces

• 1、 -. "REMEDY FOR DIABETES". Page/Page column 22. . Retrieved 2010/04/23.