2,6-Dimethylpiperazine

Base Information

• Chemical Name: 2,6-Dimethylpiperazine
• CAS No.: 108-49-6
• Molecular Formula: C6H14N2
• Molecular Weight: 114.191
• Hs Code.: 29335990
• European Community (EC) Number: 203-588-9
• NSC Number: 49197
• DSSTox Substance ID: DTXSID70883302
• Nikkaji Number: J147.994F
• Mol file: 108-49-6.mol

Synonyms:2,6-Dimethylpiperazine;108-49-6;Piperazine, 2,6-dimethyl-;3,5-dimethylpiperazine;EINECS 203-588-9;NSC 49197;(2,6-cis-dimethyl)piperazine;NSC49197;2,6-dimethylpiperazin;2,6 dimethylpiperazine;2,6-dimehtylpiperazine;Piperazine,6-dimethyl-;2,6-di-methylpiperazine;2,6-dimethyl-piperazine;3,5-dimethyl-piperazine;SCHEMBL190032;2,6-Dimethylpiperazine, 97%;2,6-DIMETHYL PIPERAZINE;DTXSID70883302;MFCD00005956;NSC-49197;AKOS009156488;AB48104;AB48105;AM81382;CS-W013629;PB23510;PB39554;AS-10841;FT-0623896;FT-0694464;FT-0771855;FT-0773399;EN300-59818;P15326;A801885;W-108715;Z916970166

Chemical Property of 2,6-Dimethylpiperazine

Chemical Property:

• Appearance/Colour: White to pale yellow crystalline powder
• Vapor Pressure: 2.31mmHg at 25°C
• Melting Point: 108-111 °C(lit.)
• Refractive Index: 1.413
• Boiling Point: 161.1 °C at 760 mmHg
• PKA: 9.38±0.60(Predicted)
• Flash Point: 45 °C
• PSA: 24.06000
• Density: 0.824 g/cm³
• LogP: 0.61380
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• Sensitive.: Light Sensitive & Hygroscopic
• XLogP3: 0
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 114.115698455
• Heavy Atom Count: 8
• Complexity: 64.9

Purity/Quality:

2,6-Dimethylpiperazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s): F,Xi,C
• Hazard Codes: F,Xi,C
• Statements: 11-36/37/38
• Safety Statements: 26-36-16-7/8

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CC1CNCC(N1)C

Technology Process of 2,6-Dimethylpiperazine

There total 15 articles about 2,6-Dimethylpiperazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → piperazine (110-85-0) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + (RS)-2-methylpiperazine (109-07-9) + ethylenediamine (107-15-3,85404-18-8) + 1,2-diaminopropan (78-90-0,10424-38-1) + 3,5-dimethylpiperazine (108-49-6)

Guidance literature:

With ammonia; hydrogen; Raney nickel; In water; at 200 ℃; under 15001.5 - 150015 Torr; Product distribution / selectivity; Autoclave;

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-Amino-1-propanol (6168-72-5) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + (RS)-2-methylpiperazine (109-07-9) + 1,2-diaminopropan (78-90-0,10424-38-1) + 3,5-dimethylpiperazine (108-49-6) + 2,5-dimethylpiperazine (106-55-8)

Guidance literature:

With ammonia; hydrogen; catalyst precursor whose active composition comprised 13% by weight of Cu, calculated as CuO, 28% by weight of Ni, calculated as NiO, 28% by weight of Co, calculated as CoO and 31% by weight of Zr, calculated as ZrO₂; In water; at 180 ℃; for 53h; under 150015 Torr; Product distribution / selectivity;

Reference yield:

glycerol (56-81-5,25618-55-7,64333-26-2,8013-25-0) → 2-Amino-1-propanol (6168-72-5) + N-(1-aminomethyl-2-hydroxyethyl)amine (2811-20-3) + 1,2,3-triaminopropane (21291-99-6) + 2-aminomethyl-6-methylpiperazine (1122585-40-3) + 2,5-bis(aminomethyl)piperazine (1122585-41-4) + 2-aminomethylpiperazine (130861-85-7) + 2-aminomethyl-5-methylpiperazine (136665-35-5) + (RS)-2-methylpiperazine (109-07-9) + 1,2-diaminopropan (78-90-0,10424-38-1) + 3,5-dimethylpiperazine (108-49-6) + 2,5-dimethylpiperazine (106-55-8)

Guidance literature:

With ammonia; hydrogen; catalyst precursor whose active composition comprised 50% by weight of Ni, calculated as NiO, 18% by weight of Cu, calculated as CuO, 2% by weight of Mo, calculated as MoO₃, and 30% by weight or Zr, calculated as ZrO₂; In water; at 192 ℃; for 1076h; under 150015 Torr; Product distribution / selectivity;

upstream raw materials:

1,4-dinitroso-2,6-dimethylpiperazine

N-nitroso-3,5-dimethylpiperazine

Acetol acetate

ammonia

Downstream raw materials:

7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-4-oxo-1-o-tolyl-1,4-dihydro-quinoline-3-carboxylic acid

PD 160352

7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

7-(Dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-4-methyl-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

Refernces

• 1、 Vankudoth, Krishna,Padmasri, A. Hari,Sarkari, Reema,Velisoju, Vijay Kumar,Gutta, Naresh,Sathu, Naveen Kumar,Rohita,Akula, Venugopal. "The role of Lewis acid-base pair sites in ZnO-ZnCr2O4 catalysts for cyclization: Via dehydrogenative condensation of crude glycerol and 1,2-propanediamine for the synthesis of 2,6-dimethylpyrazine". . p. 9875 - 9883. Retrieved 2017.
• 2、 Takanashi, Tsukasa,Tamura, Masazumi,Nakagawa, Yoshinao,Tomishige, Keiichi. "Structure of catalytically active Rh-In bimetallic phase for amination of alcohols". . p. 28664 - 28672. Retrieved 2014/07/22.