7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-1-(2-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Base Information

• Chemical Name: 7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-1-(2-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
• CAS No.: 164662-47-9
• Molecular Formula: C₂₂H₂₁F₂N₃O₃
• Molecular Weight: 413.424
• Mol file: 164662-47-9.mol

Synonyms:

Chemical Property of 7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-1-(2-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Chemical Property:

• Vapor Pressure: 2.57E-15mmHg at 25°C
• Boiling Point: 601.5°Cat760mmHg
• Flash Point: 317.6°C
• Density: 1.341g/cm³

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-1-(2-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

There total 5 articles about 7-(3,5-dimethylpiperazin-1-yl)-6-fluoro-1-(2-fluorophenyl)-4-oxo-1,4-dihydroquinoline-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (1027017-16-8) + 3,5-dimethylpiperazine (108-49-6) → 7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (164662-47-9)

Guidance literature:

In acetonitrile;

DOI:10.1021/jm00015a021

Reference yield:

2,4,5-trifluorobenzoic acid (446-17-3) → 7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (164662-47-9)

Guidance literature:

Multi-step reaction with 5 steps

1: 1.) (COCl)2, 2.) C₃H₇MgCl / 1.) CH₂Cl₂, DMF, 2.) THF

2: 1.) Ac₂O / 2.) Et₂O

3: NaH / tetrahydrofuran

4: 6 M HCl

5: 69 percent / acetonitrile

With hydrogenchloride; oxalyl dichloride; C₃H₇MgCl; acetic anhydride; sodium hydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00015a021

Reference yield:

ethyl 2,4,5-trifluorobenzoylacetate (98349-24-7) → 7-(3,5-Dimethyl-piperazin-1-yl)-6-fluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid (164662-47-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1.) Ac₂O / 2.) Et₂O

2: NaH / tetrahydrofuran

3: 6 M HCl

4: 69 percent / acetonitrile

With hydrogenchloride; acetic anhydride; sodium hydride; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm00015a021

upstream raw materials:

6,7-Difluoro-1-(2-fluoro-phenyl)-4-oxo-1,4-dihydro-quinoline-3-carboxylic acid

3,5-dimethylpiperazine

2,4,5-trifluorobenzoic acid

ethyl 2,4,5-trifluorobenzoylacetate

Refernces