1H-Indole, 6-methyl-4-nitro-

Base Information

• Chemical Name: 1H-Indole, 6-methyl-4-nitro-
• CAS No.: 880086-93-1
• Molecular Formula: C₉H₈N₂O₂
• Molecular Weight: 176.175
• Hs Code.: 2933990090
• Mol file: 880086-93-1.mol

Synonyms:RD-0166;6-Methyl-4-nitro indole;

Chemical Property of 1H-Indole, 6-methyl-4-nitro-

Chemical Property:

• PSA: 61.61000
• LogP: 2.90770
• Storage Temp.: 2-8°C

Purity/Quality:

99% ^*data from raw suppliers

6-Methyl-4-nitroindole ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1H-Indole, 6-methyl-4-nitro-

There total 5 articles about 1H-Indole, 6-methyl-4-nitro- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl 2,5-dimethyl-3-nitrophenylimidoformate (880086-94-2) → 6-methyl-4-nitro-1H-indole (880086-93-1)

Guidance literature:

With potassium ethoxide; oxalic acid diethyl ester; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 40 ℃; for 1h;

Reference yield:

ethyl 2,5-dimethyl-3-nitrophenylimidoformate → 6-methyl-4-nitro-1H-indole (880086-93-1)

Guidance literature:

With potassium ethoxide; oxalic acid diethyl ester; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 40 ℃; for 1h; distillation apparatus;

Reference yield:

para-xylene (106-42-3) → 6-methyl-4-nitro-1H-indole (880086-93-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sulfuric acid; nitric acid / 80 °C / Cooling with ice

2: iron; acetic acid / 3 h / 110 °C

3: toluene-4-sulfonic acid / 0.75 h / 120 °C

4: potassium ethoxide; oxalic acid diethyl ester / dimethyl sulfoxide / 1 h / 40 °C

With sulfuric acid; potassium ethoxide; nitric acid; iron; toluene-4-sulfonic acid; acetic acid; oxalic acid diethyl ester; In dimethyl sulfoxide;

upstream raw materials:

ethyl 2,5-dimethyl-3-nitrophenylimidoformate

para-xylene

2,5-dimethyl-1,3-dinitrobenzene

2,5-dimethyl-3-nitroaniline

Refernces

• 1、 -. "SPIROLACTAM TRICYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 104-105. . Retrieved 2008/06/13.
• 2、 -. "TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS". Page/Page column 60. . Retrieved 2008/06/13.