ethyl 2,5-dimethyl-3-nitrophenylimidoformate

Base Information

• Chemical Name: ethyl 2,5-dimethyl-3-nitrophenylimidoformate
• CAS No.: 880086-94-2
• Molecular Formula: C₁₁H₁₄N₂O₃
• Molecular Weight: 222.244
• Mol file: 880086-94-2.mol

Synonyms:ethyl 2,5-dimethyl-3-nitrophenylimidoformate

Chemical Property of ethyl 2,5-dimethyl-3-nitrophenylimidoformate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ethyl 2,5-dimethyl-3-nitrophenylimidoformate

There total 3 articles about ethyl 2,5-dimethyl-3-nitrophenylimidoformate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2,5-dimethyl-3-nitroaniline (62564-50-5) + orthoformic acid triethyl ester (122-51-0) → ethyl 2,5-dimethyl-3-nitrophenylimidoformate (880086-94-2)

Guidance literature:

With toluene-4-sulfonic acid; at 120 ℃; for 0.75h; distillation apparatus;

Reference yield:

2,5-dimethyl-1,3-dinitrobenzene (609-92-7) → ethyl 2,5-dimethyl-3-nitrophenylimidoformate (880086-94-2)

Guidance literature:

Multi-step reaction with 2 steps

1: iron; acetic acid / 3 h / 110 °C

2: toluene-4-sulfonic acid / 0.75 h / 120 °C

With iron; toluene-4-sulfonic acid; acetic acid;

Reference yield:

para-xylene (106-42-3) → ethyl 2,5-dimethyl-3-nitrophenylimidoformate (880086-94-2)

Guidance literature:

Multi-step reaction with 3 steps

1: sulfuric acid; nitric acid / 80 °C / Cooling with ice

2: iron; acetic acid / 3 h / 110 °C

3: toluene-4-sulfonic acid / 0.75 h / 120 °C

With sulfuric acid; nitric acid; iron; toluene-4-sulfonic acid; acetic acid;

upstream raw materials:

2,5-dimethyl-3-nitroaniline

orthoformic acid triethyl ester

para-xylene

2,5-dimethyl-1,3-dinitrobenzene

Downstream raw materials:

6-methyl-4-nitro-1H-indole

Refernces

• 1、 -. "SPIROLACTAM TRICYCLIC CGRP RECEPTOR ANTAGONISTS". Page/Page column 104-105. . Retrieved 2008/06/13.
• 2、 -. "TRICYCLIC ANILIDE SPIROHYDANTOIN CGRP RECEPTOR ANTAGONISTS". Page/Page column 60. . Retrieved 2008/06/13.