2-Heptenoic acid, 4,4-dimethyl-7-(2-oxo-3-cyclohexen-1-yl)-, ethyl ester, (E)-

Base Information

• Chemical Name: 2-Heptenoic acid, 4,4-dimethyl-7-(2-oxo-3-cyclohexen-1-yl)-, ethyl ester, (E)-
• CAS No.: 91200-48-5
• Molecular Formula: C17H26O3
• Molecular Weight: 278.392
• Mol file: 91200-48-5.mol

Synonyms:

Chemical Property of 2-Heptenoic acid, 4,4-dimethyl-7-(2-oxo-3-cyclohexen-1-yl)-, ethyl ester, (E)-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-Heptenoic acid, 4,4-dimethyl-7-(2-oxo-3-cyclohexen-1-yl)-, ethyl ester, (E)-

There total 5 articles about 2-Heptenoic acid, 4,4-dimethyl-7-(2-oxo-3-cyclohexen-1-yl)-, ethyl ester, (E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + (E)-4,4-Dimethyl-7-(2-oxo-cyclohex-3-enyl)-hept-2-enal → 6-(6-ethoxycarbonyl-4,4-dimethylhex-5-enyl)cyclohex-2-enone (91200-48-5)

Guidance literature:

With sodium hydride; In 1,2-dimethoxyethane; for 1h; Ambient temperature;

Reference yield: 90.0%

diethoxyphosphoryl-acetic acid ethyl ester (867-13-0) + 2,2-Dimethyl-5-(2-oxo-cyclohex-3-enyl)-pentanal (110949-92-3) → 6-(6-ethoxycarbonyl-4,4-dimethylhex-5-enyl)cyclohex-2-enone (91200-48-5)

Guidance literature:

With sodium hydride;

DOI:10.1016/S0040-4039(01)81189-8

Reference yield:

6-(5-hydroxy-4,4-dimethylpentyl)cyclohex-2-enone (90122-48-8) → 6-(6-ethoxycarbonyl-4,4-dimethylhex-5-enyl)cyclohex-2-enone (91200-48-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 90 percent / pyridinium chlorochromate / CH₂Cl₂ / 2 h

2: 100 percent / 60 percent sodium hydride / 1,2-dimethoxy-ethane / 1 h / Ambient temperature

With sodium hydride; pyridinium chlorochromate; In 1,2-dimethoxyethane; dichloromethane;

upstream raw materials:

diethoxyphosphoryl-acetic acid ethyl ester

2,2-Dimethyl-5-(2-oxo-cyclohex-3-enyl)-pentanal

6-(5-hydroxy-4,4-dimethylpentyl)cyclohex-2-enone

5-(2-methoxyphenyl)-2,2-dimethylpent-4-en-1-ol

Refernces

• 1、 Ihara, Masataka,Toyota, Masahiro,Fukumoto, Keiichiro,Kametani, Tetsuji. "STEREOCONTROLLED CONSTRUCTION OF A SPIRO FUSED BICYCLOOCTANE RING SYSTEM BY THE INTRAMOLECULAR DOUBLE MICHAEL REACTION". . p. 2167 - 2170. Retrieved 2007/10/02.