FENOFIBRIC ACID, HYDROXYMETHYL

Base Information

• Chemical Name: FENOFIBRIC ACID, HYDROXYMETHYL
• CAS No.: 54419-31-7
• Molecular Formula: C₁₇H₁₇ClO₄
• Molecular Weight: 320.773
• Mol file: 54419-31-7.mol

Synonyms:Fenirofibrate;LF 2151; LF 433

Chemical Property of FENOFIBRIC ACID, HYDROXYMETHYL

Chemical Property:

• Vapor Pressure: 7.89E-11mmHg at 25°C
• Melting Point: 130-132 ºC
• Boiling Point: 500.3 ºCat 760 mmHg
• Flash Point: 256.4 ºC
• Density: 1.297 g/cm³
• Storage Temp.: -20°C Freezer
• Solubility.: Ethyl Acetate, DMSO, Methanol

Purity/Quality:

98% ^*data from raw suppliers

Fenirofibrate-d6 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: A labelled metabolite of Fenofibrate

Technology Process of FENOFIBRIC ACID, HYDROXYMETHYL

There total 6 articles about FENOFIBRIC ACID, HYDROXYMETHYL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

fenofibric acid (42017-89-0) → fenirofibrate (54419-31-7,123612-42-0,123612-43-1)

Guidance literature:

With CYP₃A₄;

DOI:10.1124/dmd.115.065060

Reference yield:

4-((4-chlorophenyl)(hydroxy)methyl)phenol (61001-99-8) → fenirofibrate (54419-31-7,123612-42-0,123612-43-1)

Guidance literature:

With sodium hydroxide;

Reference yield:

4-chloro-4'-hydroxybenzophenone (42019-78-3) → fenirofibrate (54419-31-7,123612-42-0,123612-43-1)

Guidance literature:

Multi-step reaction with 4 steps

1: sodium hydroxide

2: sulfuric acid

3: potassium borohydride

4: sodium hydroxide

With sodium hydroxide; potassium borohydride; sulfuric acid;

upstream raw materials:

4-((4-chlorophenyl)(hydroxy)methyl)phenol

4-chloro-4'-hydroxybenzophenone

fenofibric acid

fenofibrate

Refernces